Grape Seed Proanthocyanidin Alleviates Oxidative Stress and Apoptosis Involved in Liver of Hyperthyroid Mice

Abstract

Objectives: Thyroid hormones control the basal metabolic pace of hepatocytes, and can make oxidative harm hepatic frameworks. The reason for this investigation was to investigate how hyperthyroidism-prompted liver danger, oxidative pressure and apoptosis changes could be alleviated with Grape seed proanthocyanidin extract (GSPE). This investigation assessed some biochemical, histological and immunohistochemical changes in post pubertal hyperthyroidism and its effect on liver capacity and structures. Notwithstanding the enhancing job of Grape seed proanthocyanidin remove (GSPE) supplementation was analyzed. Materials and Methods: Fifty male Swiss albino mice were randomly divided into 5 groups (G1, Control; G2, GSPE; G3, Eltroxin-induced hyperthyroid mice; G4, Post treated hyperthyroid with GSPE; G5, Self-treated hyperthyroid mice). Results: Our results revealed that, a significant increase in serum T3, T4, ALT, AST, ALP, liver MDA, P53 levels, injury and P53 expression in hyperthyroid mice when compared to control and GSPE. In contrast; serum albumin, liver catalase, GSH, SOD and Bcl2 were decrease in hyperthyroid mice. Treatment of hyperthyroid mice with GSPE advantages in improving the adverse effect of hyperthyroidism and moreover the histopathological and P53 expression result approves this finding. Conclusions: GSPE can be used in hyperthyroidism treatment to help propylthiouracil or carbimazole or methimazole therapy.