HIF1A Expression is a Common Cause for the Warburg Effect in Lung Cancer Tumors, Cervical Cancer Tumors, and Brain Cancer Tumors
International Research Journal of Oncology · pp. 177–184 · Published 28 Aug 2023
Abstract
This paper focuses on the relationship between HIF1A expression and the warburg effect. Considering that the warburg effect is a hallmark of cancer, it’s possible that it could be caused by a common mechanism within tumor microenvironments. This paper considers the common cause of that to be hypoxia and HIF1A overexpression. By experimenting on mouse models and cancer cell lines for lung tumors, brain tumors, and cervical tumors, we investigate to find whether HIF1A overexpression is, in fact, a common cause for the warburg effect among the tested cancer types. The results were very promising and with this understanding, treatments can be developed to block HIF1A expression which would cause the inhibition of the warburg effect and decrease cancer cell proliferation rate.
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