The Cell Based Model of in-vivo Coagulation:  A Work in Progress

Biswaprakash Patri; Anubhav Abinash Sahu; Souravi Pal; Sukumar Chakravarty

doi:10.9734/IBRR/2016/26906

Research Article Open access CC BY 4.0

The Cell Based Model of in-vivo Coagulation: A Work in Progress

Biswaprakash Patri, Anubhav Abinash Sahu, Souravi Pal, Sukumar Chakravarty

International Blood Research & Reviews · pp. 1–10 · Published 15 Jun 2016

10.9734/IBRR/2016/26906

Abstract

The goal of this article is to review the evolution of theories of coagulation and their proposed models to serve as a tool. When reviewing the research and practice literature that was published in the context of these theories over time, including the critical contribution of cells, we have observed a model based on work of many workers, in which Hemostasis is regulated by various properties of cell surface, which occurs in vivo. The coagulation occurs not as a cascade/waterfall, but occurs in 4 overlapping steps-(i) Initiation, (ii) Amplification, (iii) Propagation, (iv) Termination. Cell Based model has given an insight into the pathophysiological mechanism of certain coagulation disorders which were till now ill understood.

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Biswaprakash Patri, Anubhav Abinash Sahu, Souravi Pal, Sukumar Chakravarty (2016). The Cell Based Model of in-vivo Coagulation: A Work in Progress. International Blood Research & Reviews , 1–10. https://doi.org/10.9734/IBRR/2016/26906

Affiliations

Biswaprakash Patri — Department of Pathology, Hitech-Medical College and Hospital, Bhubaneswar, Odisha, India
Anubhav Abinash Sahu — Department of Pathology, Hitech-Medical College and Hospital, Bhubaneswar, Odisha, India
Souravi Pal — Department of Pathology, Hitech-Medical College and Hospital, Bhubaneswar, Odisha, India
Sukumar Chakravarty — Department of Pathology, Hitech-Medical College and Hospital, Bhubaneswar, Odisha, India

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