Autophagy: A Critical Review of Cellular Homeostasis and Pathophysiology
Sakshi Deogade, Shubham Shende, Chandani Prasad, Moni Dorlikar, Praful Urade, Lalchand Devhare
Asian Journal of Advanced Research and Reports · pp. 280–287 · Published 8 Feb 2025
10.9734/ajarr/2025/v19i2908Abstract
Autophagy, a conserved cellular process, is essential for maintaining cellular homeostasis by degrading and recycling damaged organelles and misfolded proteins. It has garnered significant attention due to its dual role in health and disease. This review explores the mechanisms of autophagy, its regulation, and its implications in various physiological and pathological contexts, including cancer, neurodegeneration, and immunity. Further research is essential to unravel the complexities of autophagy, particularly regarding its role in different tissues and organs under various physiological and pathological conditions. As we move forward, the integration of cutting-edge technologies and innovative approaches will be key to translating our understanding of autophagy into effective clinical interventions that can be tailored to individual patient needs.
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