Aims: Carboxylesterases (CE) convert carboxylic esters to alcohols and carboxylic acids. CE is a protective factor in the brain cells categorized as phase-I drug-metabolizing enzymes. Therefore we aim to find out the difference CE specific activity for Brain tumors as compared to...
Renal carcinoma is a tumor with high metatstatic risk, compromising its prognosis, often fatal. Involvement in the inferior vena cava is present in 15-20% of metastatic locations with the possibility of intracavitary cardiac extension in 5%. The circumstance of discovery of this...
Smoldering multiple myeloma (SMM) is a clonal plasma cell (PC) condition that falls between monoclonal gammopathy of unknown significance (MGUS) and multiple myeloma (MM). Detecting SMM patients allows for early therapy, which slows the disease's course and reduces morbidity. Thi...
Smooth muscle tumors originating from round ligament are rarewith leiomyoma being the most common type among them with unknown exact incidence. Its location at inguinal area/pubic area is confused with the clinical diagnosis of vulvar swelling, inguinal hernia, lymph node, or oth...
A 52-year-old patient from Bangladesh, known for hypertension for the last year, was taking oral antihypertensives. Nonetheless, he still had uncontrolled blood pressure, and no associated symptoms. The patient was referred to Emergency with a presenting complaint of high blood p...
This opinion article highlights the mechanism of wound healing and the impact of wound on cancer evolution and cancer therapy. Wound healing requires the proliferation and the terminal differentiation (TD) of progenitor stem cells (PSCs). PSCs are pluripotent stem cells capable o...
Retinoblastoma (RB) is the most common ocular malignancy. Presentation of this embryonal tumour in association with homozygous Sickle cell disease (HSCD) is seen for the very first time in a region with the highest prevalence of sickle cell disease and has also never been reporte...
The uses of Lactic acid bacteria as probiotics have received considerable attention as a suitable alternative to antibiotics. Bacteriocins produced by LAB are used as biopreservative in foods, with a resultant reduction in the use of chemical preservatives. A typical bacteriocin...
Background: Parathyroid carcinoma (PC) is an extremely rare tumor with estimated prevalence of about 0.005% of all cancer cases. There is no established etiology for parathyroid carcinoma; with both environmental and genetic factors may be contributing. The majority of the cases...
The management of desmoid tumors has undergone changes in recent years including active surveillance for asymptomatic and non-progressive tumors. The place of radiotherapy is contested due to significant toxicity. Radiation therapy is offered as an alternative to surgery for tumo...
Scrotal pathologies are relatively common among men, with infectious causes of the testicular diseases resulting mainly from ascending infection from the urethra, although haematogenous route have also been noted. Herein, we report a case of a 37-year-old man who presented with t...
Oculocutaneous albinism (OCA) is the most common inherited pigmentary disorder of the skin which is associated with impaired melanin biosynthesis. Clinical features of OCA are decreased pigmentation of the skin, hair, and eyes. The absence of melanin increases the risk of these p...
About 53% of colorectal cancer (CRC) patients were reported to have the Kirsten rat sarcoma viral oncogene homolog (KRAS) gene mutations. These mutations in the KRAS gene are able to render the targeted therapy agents such as monoclonal antibodies cetuximab and panitumumab ineffe...
Background: ASCUS is a borderline cytopathological diagnostic category that leaves clinicians with a dilemma regarding how to manage the patient. Triaging women with prior ASCUS results with Hr-HPV testing helps to distinguish those with true neoplastic lesions from those with re...
T-cell-based methods using genetic engineering technology are considered the most advanced treatments in cancer therapy. Chimeric antigen receptor (CAR) T-cell therapy is an innovative immunotherapy wherein autologous T-cells are genetically modified to recognize and destroy canc...