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All published articles 370

Effects of Thymoquinone and Cisplatin on C-MYC, KRAS, p53 and EGFR Gene Expression in Lung Cancer Cell Lines

Bayrakçi Onur, Karaman Taşdemir Demet, Ilhan Sedat & Işik Ahmet Ferudun · Journal of Cancer and Tumor International · 2022

Lung cancer is one of the most common causes of death.It is known that  genetic reasons in its etiology.Lung cancer has been shown to be associated with the EGFR,P53,KRAS and c-MYC genes.Thymoquinone is an antitumoral and antineoplastic bioactive substance procured from Nigella s...

Open access Research Article 10.9734/jcti/2022/v12i4220

Management Outcome of Multi-sites Keloids of Multiple Aetiologies in a Young Female Nigerian: A Case Report

Rotimi Sunday Ajani & Adeniyi Abidemi Adenipekun · Journal of Cancer and Tumor International · 2022

Background: Keloids are exaggerated cutaneous scars with a preponderance of fibrous tissue that may complicate wound healing in people that are predisposed to its development. Its management could be challenging with very high probability of recurrence following surgical excision...

Open access Research Article 10.9734/jcti/2022/v12i3219

A Rare Case Report of Radionecrosis Mandible after Irradiation for Breast Cancer

Akhilesh Prathap, George Varghese, R. S. Nidhin, Geethu Philo Varghese & R. B. Aiswarya · Journal of Cancer and Tumor International · 2022

Management of irradiated patients with cancer in the head and neck region is a challenging scenario. Radiotherapy promotes cellular and vascular insufficiency that results in a low response rate in the healing. Consequently, surgical procedures in irradiated tissues present high...

Open access Research Article 10.9734/jcti/2022/v12i430188

Diagnostic Challenges in Osteoradionecrosis of the Jaw

Busra Yilmaz, Efsun Somay, Ahmet Kucuk & Erkan Topkan · Journal of Cancer and Tumor International · 2022

Osteoradionecrosis of the jaws (ORNJ) is a severe radiotherapy (RT) complication that occurs in 2% to 22% of individuals with head and neck cancers (HNC) who are treated with RT or concurrent chemo-RT. The accurate diagnosis of ORNJ is crucial for appropriate and prompt managemen...

Open access Research Article 10.9734/jcti/2022/v12i430187

A Rare Breast Carcinosarcoma in a Young Female

Mohammad Al-Share, Michleen Al-Awabdeh, Maysaa Al-Khalaileh, Mohammad Abu-Jeyyab & Hanan Al-Asbahi · Journal of Cancer and Tumor International · 2022

Metaplastic breast cancer (MBC) is a rare aggressive type of breast cancer, as this form of cancer makes up only 1% of overall breast cancers. It mainly presents with a rapid-growing mass.  Establishing the diagnosis is based on histopathology, as imaging studies show the same fe...

Open access Research Article 10.9734/jcti/2022/v12i430185

Endoscopic Assisted Supraorbital Approach for Tumors of Anterior and Middle Skull Base

Mohamed E. Shamia, Ahmed M. Abdelmonem, Tariq Awad, Nader E. Negm & Medhat M. Kamal · Journal of Cancer and Tumor International · 2022

Background Data: The supraorbital eyebrow approach is a minimally invasive keyhole technique that offers wide access to the anterior skull base and parasellar region using the subfrontal corridor, with assistances of neuroendoscopy The approach through the eyebrow permits access...

Open access Research Article 10.9734/jcti/2022/v12i430183

Detection of Androgen Receptor Gene Polymorphism in Sudanese Patients of Prostate Cancer in Khartoum State

Jumaa Abuajila Salem Salama, Dawelbiet Abdelaal Yahia, Mohamed Maysara Ali, Ahmed Elhadi Elsadig & Tarig A. M. Hamid · Journal of Cancer and Tumor International · 2022

Background: Prostate cancer (PCa) is the most commonly diagnosed solid tumor among men. Genetic susceptibility had been proposed among the risk factors for the development of this cancer. Aim: To investigate the effect of androgen receptor gene polymorphism in the susceptibility...

Open access Research Article 10.9734/jcti/2022/v12i430184

A Case Report of Management of Multiple Peri-orbital Cysts (Eccrine Hidrocystoma) in a 35-Year Old Woman

E. S. Amadi, M. N. Amaewhule & C. Okejim · Journal of Cancer and Tumor International · 2022

Background: Hidrocystoma is a rare benign swelling(tumour) of sweat glands also known as the cystic form of hidroadenoma, cystadenomas, sudoriferous cysts, and Moll’s gland. It has no racial or sex predilection. Its rarity and site of occurrence makes its management challenging d...

Open access Research Article 10.9734/jcti/2022/v12i430182

Sub-Classification of Triple-Negative Breast Cancer using Androgen Receptor and Cytokeratin 5/6

Leonard Derkyi-Kwarteng, L. Ahenkorah Fondjo, P. Kafui Akakpo, Eric Aidoo, Ato Brown, Ellen Ola, Stephanie K. A. Adjei & Francis Agyemang · Journal of Cancer and Tumor International · 2022

Background:  Triple negative breast cancer (TNBC) is a unique heterogenous subtypes of breast cancer which is characterized by negative estrogen, progesterone, and human epidermal growth factor receptor (HER-2) status. TNBC displays different molecular phenotype with which basal-...

Open access Research Article 10.9734/jcti/2022/v12i330181

Prevalence of Risk Factors and Lifestyle Choices Associated with Increased Cancer in Participants from Trinidad and Tobago

A. Justiz-Vaillant, L. Gardiner, L. Maharaj, M. Mohammed, M. Niles, L. Ramsingh, M. Seegobin, M. Simon & M. Surajbally · Journal of Cancer and Tumor International · 2022

The prevalence of risk factors for cancer among demographics, such as age, gender, and ethnicity, as well as lifestyle choices such as alcohol consumption, smoking, and diet were explored in a Trinidadian population. This cross-sectional study was conducted with participants aged...

Open access Research Article 10.9734/jcti/2022/v12i330180

Spectrum of Benign Breast Disease; a Critical Review of Therapy: A Single – Center Experience

Vijay Pratap Singh, Akash Kumar Singh, Pranab Kumar Verma, Sumantra Sircar, Vishal Mohan Singh & Arun Kumar Jha · Journal of Cancer and Tumor International · 2022

Background: A benign breast condition is one that is not cancer. These conditions often go away on their own or are easily treated. Because a few benign breast conditions can increase your risk of getting cancer in the future, you may need to have follow-up tests or exams with yo...

Open access Research Article 10.9734/jcti/2022/v12i330178

Prevention of Adjuvant Treatment Induced Cardiotoxicity in Egyptian Breast Cancer (BC) Patients: A Randomized Prospective Study

Azza M. Adel, Niven M. Gado, Dina Ragab, Yasmin Abdelrazek Ali, Ahmed Samir & Hagar Ibrahim · Journal of Cancer and Tumor International · 2022

Background: Adjuvant Anthracyclines Chemotherapy (ANTC) and trastuzumab have been documented to prolong survival in patients with breast cancer (BC). However, these drugs are also well known to induce left ventricular systolic dysfunction (LVSD). Multiple studies have shown that...

Open access Research Article 10.9734/jcti/2022/v12i330177

Lung Cancer: Solitary Pulmonary Nodule

Ashraf ALakkad, Aref Chelal & James Aitchison · Journal of Cancer and Tumor International · 2022

A 55-year old, middle-aged man, known for hypertension and dyslipidemia, presented to the OPD with complaints of fever along with a mild dry cough. There was no shortness of breath or chest pain associated with the patient’s complaints. Therefore, as a seemingly obvious diagnosis...

Open access Research Article 10.9734/jcti/2022/v12i230174

Breast Cancer among Young Women in Douala, Cameroon: Epidemiological, Clinical, Behavioural Characteristics and Risk Factors

Idriss Ntatou Lemouchele, Suzi Pascale Mbougang, Esther Dina Bell, Cécile Okalla Ebongue, Loick Pradel KOJOM FOKO, Elisée Libert Embolo Enyegue, Rachel De Grâce Tayou Tchuente, Eric Fouelifack Nzeko, Annie Rosalie Ngono Ngane & Martin Luther Koanga Mogtomo · Journal of Cancer and Tumor International · 2022

Aims: This study aimed at determining epidemiological, clinical, behavioural and risk factors for breast cancer (BC) among young women living in Cameroon. Study Design:  Cross-sectional case-control study. Place and Duration of Study: The study took place at the Oncology departme...

Open access Research Article 10.9734/jcti/2022/v12i230173