Aims: Advanced Hepatocellular carcinoma (HCC) is a major health problem with limited treatment options. The Sorafenib monothearpy is the only efficacious systemic treatment agent showing a survival benefit in these patients. In our study, we evaluated the efficacy and tolerabilit...
Open access
Research Article10.9734/JCTI/2016/22142
Background: Primary synovial sarcoma of the prostate gland (PSSP) is rare and most clinicians would be unfamiliar with its biological behaviour. Aim: To review the literature on PSSP. Methods: Various internet data bases were searched. Literature Review: PSSP is extremely rare wi...
Open access
Research Article10.9734/JCTI/2016/19541
Aims: Evaluate the role of neoadjuvant chemoradiotherapy (CRT) followed by an additional cycle of chemotherapy and total mesorectal excision (TME) in patients with locally advanced rectal cancer on the rate of pathologic complete response (pCR) and tumor downstaging, their impac...
Open access
Research Article10.9734/JCTI/2016/22520
The papillary and follicular histological sub-types of thyroid cancer are referred to as differentiated thyroid cancers. When these tumors metastasize, they rarely do so to the liver. Hepatic metastasis is very uncommon in this group of cancers and has only been reported in a han...
Open access
Research Article10.9734/JCTI/2015/20790
Aims: The aim of the study was to assess the frequency of Kirsten rat sarcoma viral oncogene homolog (KRAS) gene mutation, perform clinicopathologic characterization of KRAS mutated colorectal cancer (CRC), evaluation of the prognostic significance of KRAS mutations and their inf...
Open access
Research Article10.9734/JCTI/2015/20417
Background: Doxorubicin is a potent chemotherapeutic drug. The clinical usefulness of doxorubicin has been limited largely by the risk of cardiomyopathy and life-threatening heart failure. Therefore early identification of cardiotoxicity represents a primary goal for cardiologist...
Open access
Research Article10.9734/JCTI/2015/19169
Background: Primary squamous cell carcinoma of renal pelvis/kidney (PSCCRP/K) is rare with controversies regarding its histogenesis. Aim: To review the literature. Methods: Various internet data bases were searched. Literature Review: Few cases of PSCCRP/K have been reported wit...
Open access
Research Article10.9734/JCTI/2015/19631
Aims: Myofibroblastoma (MFB) is an unusual benign mesenchymal tumour which has neoplastic cells showing a variable myofibroblastic differentiation at morphologic, immunohistochemical and ultrastructural levels. MFB is commonly seen in adult population with age range of 36-67 year...
Open access
Research Article10.9734/JCTI/2015/20633
Aims: There is growing evidence that the neutrophil to lymphocyte ratio (NLR) may be used as a prognostic factor in many head and neck cancer types. We aimed to investigate the diagnostic implication of the NLR as a biological marker in predicting the malignancy of laryngeal lesi...
Open access
Research Article10.9734/JCTI/2015/20511
Background: Adenocarcinomas of the prostate gland are commonly encountered globally but other uncommon variants of carcinoma of the prostate are sporadically encountered including primary sarcomatoid carcinoma of the prostate (PSCP). Aims: To review the literature of PSCP. Method...
Open access
Research Article10.9734/JCTI/2015/19516
Aim: The association between the clinical and histopathological features of dysplastic nevi (DN), and the risk of melanoma is not clearly known. Thus, the aim of the present study is to determine if there is an association between the clinical and histopathological features of DN...
Open access
Research Article10.9734/JCTI/2015/19696
Aims: Claudins are major transmembrane proteins of tight junctions. As the disruption of their function have important impact on tumorogenesis, invasion and metastasis. Claudins became a focus of interest for targeting therapies. Although their expression profiles have been studi...
Open access
Research Article10.9734/JCTI/2015/19336
Neuroblastoma is the most common solid abdominal tumor in children under the age of 2 years and accounts for approximately 15% of childhood mortality due to cancer. Its clinical behavior can vary from spontaneous regression to rapid fatal progression and anywhere in between (e.g....
Open access
Research Article10.9734/JCTI/2015/16165
Erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis are rare and severe cutaneous syndrome that are usually drug related. Aromatic oral anticonvulsants (e.g.: phenobarbital, phenytoin, carbamazepine) are recognized as the most common cause of these disord...
Open access
Research Article10.9734/JCTI/2015/18387
Triple-negative breast cancer is a type of aggressive breast cancer without the immunohistochemical expression of estrogen receptors, progesterone receptors and human epidermal growth factor receptor-2; with poor prognosis, greater relapse risk and worse survival in general. Its...
Open access
Research Article10.9734/JCTI/2015/18131