Pulmonary metastasis rarely originates from a benign tumour, but may occur from giant-cell tumours of bone (GCT). It occurs most frequently in recurrent cases and may result in poor outcomes. We report a case with pulmonary metastases from huge ulcerated recurrent GCT at distal u...
Open access
Research Article10.9734/JCTI/2015/17286
Aims: To present 12 new variants of uracil mustard having drug-like properties and cytotoxic functional group, by utilizing uracil mustard (uramustine) as a lead compound. Utilize rigorous substructure and similarity of a molecular scaffold to determine drug like variants. Physic...
Open access
Research Article10.9734/JCTI/2015/17780
Colon cancer is steadily increasing in Africa with high mortality and it is a pathological consequence of persistent oxidative stress. Kolaviron an active biflavonoid, has been shown to possess antioxidant, anti-lipid peroxidation and chemopreventive properties. The present study...
Open access
Research Article10.9734/JCTI/2015/16809
Various malignancies have been associated with ectopic adrenocorticotropin hormone production causing paraneoplastic Cushing’s syndrome. The most common culprits are small cell lung carcinoma, carcinoid tumors and medullary cancer of the thyroid. Early suspicion and appropriate w...
Open access
Research Article10.9734/JCTI/2015/16817
Aims: To clarify the role of trace elements in the etiology and the pathogenesis of the Ewing's sarcoma, a non-destructive neutron activation analysis with high resolution spectrometry of long-lived radionuclides were performed. Methodology: The silver (Ag), cobalt (Co), chromium...
Open access
Research Article10.9734/JCTI/2015/17464
Primary leiomyosarcoma of the kidney is a rare tumor with an aggressive behavior. However, reported literature is very limited. We report a case of renal leiomyosarcoma in a 46 years old woman presenting with a left sided abdominal mass. Computed tomography scan of the abdomen re...
Open access
Research Article10.9734/JCTI/2015/16798
Aim: The present investigation was aimed at assessing the antiproliferative and apoptotic potential of the hydroalcoholic extract of X. strumarium on HeLa cell line. Study Design: Antitumour activity of Xanthium strumarium was checked by testing against cultured HeLa cells. Place...
Open access
Research Article10.9734/JCTI/2015/15519
Introduction: Intracranial hemangiopericytoma (HPR) is a highly vascular tumors which is exceptional in children. They may present management difficulties in some cases. Clinical Presentation: The authors report the case of a 15 year-old female presented with symptoms of increase...
Open access
Research Article10.9734/JCTI/2015/15723
Background: Head and neck cancer includes several malignancies that originate in the paranasal sinuses, nasal cavity, salivary glands, oral cavity, pharynx, and larynx. The burden of viral infections in cancer is high but underappreciated by much of the cancer research community....
Open access
Research Article10.9734/JCTI/2014/15874
Aims: Cancer is a major burden of disease worldwide. Each year, tens of millions of people are diagnosed with cancer around the world, and more than half of the patients eventually die from it. The present work aims to bring out the association between age, tumour location and su...
Open access
Research Article10.9734/JCTI/2014/16378