Background: Cancer cachexia is a multifactorial syndrome characterized by involuntary weight loss, skeletal muscle wasting, and systemic inflammation. It significantly impairs patient quality of life, reduces tolerance to treatment, and contributes to poor prognosis. Objective: T...
Open access
Research Article10.9734/jcti/2025/v15i3310
Bart I. Ifionu, Chukwum J. Okafor, Ufuoma Ohwo, Nkem F. Obianagha, Emmanuel I. Obeagu, Omobolanle Abioye Ogundahunsi, E. N Adejumo & Seyi Samson Enitan·Journal of Cancer and Tumor International·2025
Background: Vitamin A and D are both fat-soluble vitamins that are crucial for maintaining overall health and are highly indispensable, despite their minimal daily requirements. Their involvement in cell proliferation, differentiation, and apoptosis has linked them to the develop...
Open access
Research Article10.9734/jcti/2025/v15i3311
Introduction: Phyllodes tumors are rare type of breast cancer. Surgery still the first option of treatment; post-operative treatment is a matter of debate specially when considering radiotherapy. Many risk factors could affect the incidence of local recurrence. Aim: Study the imp...
Open access
Research Article10.9734/jcti/2025/v15i3309
Tumor Lysis Syndrome (TLS) is an acute oncologic emergency triggered by the rapid destruction of malignant cells, resulting in a cascade of metabolic derangements including hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia. This review synthesizes contemporary unde...
Open access
Research Article10.9734/jcti/2025/v15i3308
Muhydeen Damilola Badru, Tobi Ayomide Lawal, Udeichi Nnenna Chidimma, Mayowa Josiah Badmus, Francis Esther Ene, Daniel Chinaza Anyirionye, Naomi Ngozichukwuka Ajoniloju, Adegbesan Abiodun Christopher & Comfort Mary Afolabi·Journal of Cancer and Tumor International·2025
Cancer immunotherapy has revolutionized the field of oncology by enabling the immune system to target and destroy cancer cells. Therapies such as immune checkpoint inhibitors, including PD-1/PD-L1 and CTLA-4 blockade, and chimeric antigen receptor T (CAR-T) cells have shown unpre...
Open access
Research Article10.9734/jcti/2025/v15i3306
Taiwo Oluwole FABIYI, Mary Oluwabunmi Oyebode, Kehinde Oluwafemi Fabiyi, Damilola Ayodeji Akinwale, Damilola Caroline Adeoye, Paul-Miki Raluchukwu Ibekwe, Olaitan Ololade Funke, Onyinye Henrietta Okolo & Irene Adjoa Anderson·Journal of Cancer and Tumor International·2025
Personalized medicine is a revolutionary paradigm shift in the health sector, to customize medical decisions and initiatives to the distinct biological and contextual peculiarities of individual patients. This approach differs from the generalized strategies of traditional medici...
Open access
Research Article10.9734/jcti/2025/v15i3307
Paul-Miki Raluchukwu Ibekwe, Elizabeth Anuoluwa Akintayo, Cecilia Ndiuwem Okuku, Ismaila Muhammed, Fuhad Mayowa Jeje, Okun, Oseghale, Kemiki Olalekan Ademola, Muhydeen Damilola Badru & Lydia Amarachi Onwuemelem·Journal of Cancer and Tumor International·2025
Background: The existence of genetically, epigenetically, and phenotypically distinct cell populations inside and between tumors is known as tumor heterogeneity, and it is one of the main barriers to effective cancer treatment. This intricacy affects the likelihood of metastasis,...
Open access
Research Article10.9734/jcti/2025/v15i3305
Leukoplakia is a potentially malignant disorder affecting the oral cavity. Early detection and prompt treatment are the keys to prevent its malignant transformation. Various treatment modalities have been discussed in multiple literatures, broadly categorized into non-surgical an...
Open access
Research Article10.9734/jcti/2025/v15i3304
Background: Synchronous primary malignancies, characterised by the diagnosis of two or more histologically distinct cancers within six months, are uncommon, and data from Sub-Saharan Africa is limited. Their occurrence in young individuals, particularly with colorectal and ovaria...
Open access
Research Article10.9734/jcti/2025/v15i3303
Chemobrain, or chemotherapy-induced cognitive impairment (CICI), is a significant side effect affecting cancer survivors, characterized by neuroinflammation and oxidative stress. This review examines the potential role of astaxanthin, a potent antioxidant and anti-inflammatory ca...
Open access
Research Article10.9734/jcti/2025/v15i3302
Perfusion imaging is an advanced technique for evaluating the blood flow of the microvasculature of any tissue or pathology. It refers to the passing of blood from the arterial system to the vascular system through the microvasculature of tissues. It may be affected in abnormal t...
Open access
Research Article10.9734/jcti/2025/v15i3301
Background: Binucleated cells are a type of cell that contains two nuclei within their cytoplasm and are commonly observed in both normal and pathological conditions. They play essential roles in physiological processes, such as tissue repair and adaptation, and are also implicat...
Open access
Research Article10.9734/jcti/2025/v15i3300
Josiah Stephen, Ikechukwu Kanu, Nwamaka Nneka Onyedum, Edibokun Theresa Orobator, Catherine Rono, Ngwoke, Chinaza Faith, Victor Omeiza David, Wonderful Oluwatoyin Anosike & Lawrence John AJutor·Journal of Cancer and Tumor International·2025
HLA class I molecules are essential for presenting tumour antigens to cytotoxic T-cells, but their dysregulation in cancer enables immune evasion and limiting the efficacy of immunotherapies for cancer. The objective of this review is to explore the function of HLA class I change...
Open access
Research Article10.9734/jcti/2025/v15i3299
Background: There is an upsurge of cervical cancer cases worldwide, of which Ghana is no exception. However, despite the growing population of women suffering from this disease, not much research has been done. According to studies undertaken in other countries, survivors of cerv...
Open access
Research Article10.9734/jcti/2025/v15i3298
Oseghale, Ikalo David, Ikokwu, Godwin Mmaduabuchi, Ugoagwu, Kingsley Ugonna, Elizabeth Anuoluwa Akintayo, Matthew Gyang, Okiki Nosiru Quadri, Catherine Rono, Osedebamen Hilary Ralph-Okhiria & Odunvbun Praise·Journal of Cancer and Tumor International·2025
The tumor microenvironment (TME) is the complex ecosystem surrounding a tumor. It is a complex and continuously evolving entity. The TME comprises a variety of complex components, such as cancer cells, immune cells, stromal cells, and extracellular matrix, that precisely regulate...
Open access
Research Article10.9734/jcti/2025/v15i2297