Background: Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm (MPN) that originates in an abnormal pluripotent stem cell [1]. At diagnosis, all cases of CML have the characteristic t(9;22) translocation that results in the Ph chromosome [2]. Marked bone marrow (BM)...
Background: Sickle cell disease is a condition in which an individual inherit two abnormal haemoglobin genes from both parents βs/βs (HbSS) resulting in pathological state which is attributed to the sickling phenomenon, vaso-occlusion crises, infection and other complications. Ab...
This study investigated the effects of ethanolic extract of Anacardium occidentale on paracetamol induced liver toxicity in Wistar rats. Twenty (20) Wistar rats were randomly divided into four (4) groups of five (5) rats each. The groups were designated as follows; A, B, C and D....
In medical practice, examination of blood for the presence of metabolites and other constituents is vital to the prediction of the physiological, nutritional and pathological status of any individual prior to prognosis. This study investigated the effect of crude n-hexane stem ex...
Introduction: Iron deficiency anemia is a common disease prevalent mostly in developing countries Replenishing iron stores via oral route supplementation takes longer time, however for safety reasons it is considered as the most convenient route. There is always search of better...
Ibrahim Alkasoum, Maman Daou, Mahamadou Doutchi, Samaila Boubacar, Mansour Maman Anou, Mahamane Moustapha Lamine, Ramatoulaye Hamidou Lazoumar, Kamayé Moumouni, Djibo Yacouba Hamadou & Ibrahim Maman Laminou·International Journal of Research and Reports in Hematology·2019
Summary: Problem: Malnutrition and malaria are responsible for high mortality rate in Niger. The interaction between malnutrition and malaria remains controversial. Methodology: We analyzed the retrospective data (2014 and 2015) of malarious children referred to the pediatric dep...
Background: Advanced liver disease is commonly associated with complex haemostatic defects that include impaired synthesis of clotting factors and coagulation inhibitors in association with thrombocytopenia and platelets defects. Aim of the Study: It was designed to determine whe...
Iron deficiency anaemia is commonly associated with thrombocytosis, however cases of thrombocytopenia have been reported. Recurrent cases of iron deficiency with thrombocytopenia are even more unusual; therefore, we present a patient with recurrent thrombocytopenia in the setting...
Aim: To assess the serum levels of pro-inflammatory cytokines in children with sickle cell disease in steady- state and vaso-occlusive crises in comparison to healthy children of the genotype HbAA. Study Design: Case-Control study Place and Duration of Study: University of Port H...
Three and half decades following the identification of HIV, the disease remains a global health concern as people get infected with the virus which has no cure coupled with the unavailability of vaccines. The discovery of some drugs has classified the disease into a chronic disea...
Background: Opioids are a group of potent analgesic with mixed receptor activities. Pain related symptom accounts for the main reason for substance dependence among sickle cell disease (SCD) patients. Aims: The report aims to elucidate the adverse effects of opioid and its compli...
Objective: This study sought to establish the correlation between haematological parameters and inflammatory cytokines (TNF-α and IL-6) and also to compare the effects of these cytokines in HIV/AIDS patients on HAART and HAART naïve. Place and Duration of Study: Komfo Anokye Teac...
Aim: To advocate the use of newer and improved methods towards accurate diagnosis of haemoglobinopathies Case Presentation: A rare case of double heterozygous of HbD/G in a pregnant female Nigerian who had present to the antenatal clinic for routine Haemoglobin electrophoresis. S...
About 7% of the world’s population is carriers of some form of haemoglobin disorder. There are about 270 million carriers of sickle cell anemia and/or thalassemia. The level of ovarian steroids (Estradiol and progesterone) alters in puberty age girls suffering from sickle cell an...