Aim: The aim of this study was to implement an in silico bioinformatics analysis for clinically observed missense variants in human DPYD gene to investigate the effect these variants on Dihydropyrimidine dehydrogenase enzyme 's structure and function. Methods: The human DPYD gene...
Open access
Research Article10.9734/JAMPS/2018/40300
Aim: This study was carried out to investigate the effect of captopril on serum liver enzymes (AST, ALT, and ALP), total serum protein and kidney function parameters such as electrolytes (HCO3-, Cl-, Na+, and K+), urea and creatinine in Plasmodium berghei-infected mice. Methodol...
Open access
Research Article10.9734/JAMPS/2018/40599
Background: The increase in consumption of industrial processed food, economic instability consequent to global economic recession; job losses; increase incidence of diabetes and chronic kidney disease; increase steroids use; dyslipidemia; and obesity has been implicated in the g...
Open access
Research Article10.9734/JAMPS/2018/40194
Aims: To determine the influence of Aegopodium podagraria L. aerial part extract on the function of the kidney and the metabolic processes in rats receiving hydrochlorothiazide (HCTZ, 80 mg/kg). Study Design: The rats were randomly distributed to five groups: Group I: int...
Open access
Research Article10.9734/JAMPS/2018/40313
Aims: To determine the phytochemical constituents and antibacterial potential of Cynodon dactylon leaf extracts against Escherichia coli. Study Design: Experimental short-term prospective study. Place and Duration of Study: The study was conducted in Kampala International Univers...
Open access
Research Article10.9734/JAMPS/2018/39990
Aims: The aim of this study was to find out the cytotoxicity and antibacterial activity of the methanolic extract of leaf of Antidesma bunius (Family Euphorbiaceae). Place and Duration of Study: The study was carried out in August 2017 in the Department of Pharmacy, Southeast Uni...
Open access
Research Article10.9734/JAMPS/2018/40004
Background: Malaria is a major cause of morbidity and mortality in Nigeria accounting for a significant proportion of household expenditure in treatment and prophylaxis. Nigeria account for 25% of global clinical cases and mortality and also has the highest malaria burden in su...
Open access
Research Article10.9734/JAMPS/2018/31413
Aims: Malaria parasites are expected to impact the white blood cell differential of malaria patients, but reports on changes in white blood cell differentials of malaria patients are not well documented, hence this study was undertaken to determine changes in white blood cell dif...
Open access
Research Article10.9734/JAMPS/2018/38784
Introduction: Blockade of renin-angiotensin-aldosterone system (RAAS) has been shown to be beneficial in patients with hypertension, acute myocardial infarction, chronic heart failure and diabetic renal disease. However, RAAS inhibitors and diuretic therapy are associated with so...
Open access
Research Article10.9734/JAMPS/2018/39209
Title: Availability, accessibility and affordability of antimalarial drugs in North Central Nigeria Objectives: To assess the availability and affordability of antimalarial drugs in healthcare facilities as well as compare prices and affordability within and between sectors. Back...
Open access
Research Article10.9734/JAMPS/2018/32292
Introduction: Cyclophosphamide is a chemotherapeutic alkylating drug currently used in combination with other protective agents for the purpose of reducing the adverse toxic effects. Increasingly, plants have become sources of therapeutics that can help to restore host immunity t...
Open access
Research Article10.9734/JAMPS/2018/38319
Background: Motorcycle accidents occur frequently in this part of the world as a result of interface among the agent, the host and its environment resulting in fatal consequences. The objective of this study was to assess the Knowledge of, attitude and compliance with road safety...
Open access
Research Article10.9734/JAMPS/2018/39205
Ethnopharmacological Relevance: Crateva adansonii popularly known as Three-Leaf plant is used in some South Eastern part of Nigeria by traditional medicine practitioners to treat certain diseases such as infertility and infection. Aim: This research work aimed at investigating th...
Open access
Research Article10.9734/JAMPS/2017/38321
Aims: To evaluate the Anti-mycobacterial activity of Ficus sycomorus extracts by in vitro screening against susceptible strain of Mycobacterium tuberculosis to standard TB drugs. Study Design: Hospital/University based cross sectional study. Place and Duration of Study: National...
Open access
Research Article10.9734/JAMPS/2017/38201
Introduction: Polymerization shrinkage can result in gap formation between the composite material and tooth structure with subsequent plaque accumulation, which affect the esthetic quality of a restoration and initiate periodontal diseases. Aim: The aim of this study was to evalu...
Open access
Research Article10.9734/JAMPS/2017/38834