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All published articles 175

Potential Antioxidant and Anti-Proliferative Activities of Biologically Active Marine Algae Extracts

Taha A. Kumosani, Khadijah Saeed Balamash, Hanaa Ghashlan, Youssri Ahmed Mohamed, Othman A. S. Baothman, Mustafa Zeyadi, Soonham Sami Yaghmoor, Areej H. Alyahiby, Rana R. AL-Rasheed, Wafa Y. Alturkistani, Tahani M. Alghamdi, Maryam H. AL-Zahrani & Said Salama Moselhy · Journal of Pharmaceutical Research International · 2017

Background: Marine microorganisms such as algae were identified a rich sources of biologically active compounds. This study was designed to explore the in vitro antioxidant, anti-apoptotic and anti proliferative activities of different algae [Gracilaria dendroides (GD), Dictyota...

Open access Research Article 10.9734/JPRI/2017/38089

Effect of Levetiracetam in the Treatment of Refractory Seizure in Infants through EEG: The Case of the Neonatal Intensive Care Unit of Tehran’s Children’s Medical Center

Malihe Kadivar, Mahboobeh Mohammadi, Ziba Mosayebi, Reza Shervinbadv, Raziee Sangsari & Bahram Yarali · Journal of Pharmaceutical Research International · 2017

Objective: Phenobarbital, phenytoin and Benzodiazepins are the most common treatments for resistant neonatal seizure [1]. Drug of choice in the treatment of neonatal seizure should be more effective and have fewer side effects. This study examines the effect of Levetriacetam (LEV...

Open access Research Article 10.9734/JPRI/2017/33922

Assessment of Antibiotic Self-medication Pattern among University Students in Eastern Democratic Republic of the Congo

Gabriel Kambale Bunduki, Mupenzi Mumbere & François Katsuva Mbahweka · Journal of Pharmaceutical Research International · 2017

Background: Self-medication with antibiotics has been reported among university students in many countries, but no study has been conducted on this issue in Democratic Republic of the Congo (DRC). Aim: This study aimed to assess the knowledge and behaviours of university students...

Open access Research Article 10.9734/JPRI/2017/31848

The Role of Aripiprazole (An Anti-psychotic Drug) in the Resolution of Acute Peripheral Inflammation in Male Wistar Rats

L. D. Adedayo, D. A. Olawuyi, A. O. Ojo, O. Bamidele, S. A. Onasanwo & A. O. Ayoka · Journal of Pharmaceutical Research International · 2017

Aripiprazole, a known second generation anti-psychotic drug has been implicated to possess an anti-inflammatory potential, but yet not scientific adequately explored. This study investigated the role of aripiprazole in the resolution of acute peripheral inflammation in male wista...

Open access Research Article 10.9734/JPRI/2017/32601

Assessment of Anti-atopic Dermatitis Activity of Oroxylum indicum Extract Incorporated Cream

Do Hoang Thu Trang & Hoang Le Son · Journal of Pharmaceutical Research International · 2017

Aims: The search for plant-based treatments against atopic dermatitis (AD), a relapsing dermatological condition with high prevalence in tropical regions, has always been attracting special attention. Among many folk remedies for AD, Oroxylum indicum Linn (Bignoniaceae) is a comm...

Open access Research Article 10.9734/JPRI/2017/34325

Garlic (Allium sativum L.) Protects Hepatic and Renal Toxicity of Alloxan in Rats

J. S. Aprioku & F. S. Amah-Tariah · Journal of Pharmaceutical Research International · 2017

Aims: Allium sativum (Garlic) possesses antioxidant principles and is consumed widely as a nutritional agent and for medicinal purposes. This work investigated the effects of aqueous Garlic bulb extract on alloxan-induced plasma elevations of hepatic enzymes and renal biochemical...

Open access Research Article 10.9734/JPRI/2017/34909

Synthesis of Some Novel Semicarbazone and Thiosemicarbazone Derivatives of Isatin as Possible Biologically Active Agents

Masoumeh Divar, Ali Khalafi-Nezhad, Kamiar Zomorodian, Razieh Sabet, Zahra Faghih, Maryam Jamali, Hasti Pournaghz & Soghra Khabnadideh · Journal of Pharmaceutical Research International · 2017

Aims: The development of new beneficial agents is one of the crucial aims in medicinal chemistry. Isatin is considered as a vital class of bioactive compounds exhibiting different biological activities. A series of nine new Semicarbazone (12a-i) and six new Thiosemicarbazone (14a...

Open access Research Article 10.9734/JPRI/2017/35243

Nephroprotective Effect of Phoenix reclinata Total Crude Root Extract on Tenofovir Induced Kidney Damage in Wistar Albino Rats

Cissy B. Namuleme, Kokas Ikwap, Andrew Tamale, Gabriel Tumwine, John Kateregga & Charles D. Kato · Journal of Pharmaceutical Research International · 2017

Tenofovir (TDF), used in combination with other antiretroviral agents, is an effective therapy for HIV infection. However, prolonged use of this drug is limited by a life threatening nephrotoxicity. Phoenix reclinata is a common palm species native to tropical Africa and is commo...

Open access Research Article 10.9734/JPRI/2017/34247

Performance Optimization of Sustained Release Arginine Alginate Microbeads with a Natural Polysaccharide

Ritesh Kumar Tiwari, Lalit Singh & Vijay Sharma · Journal of Pharmaceutical Research International · 2017

Objectives: The design of effective and safe novel drug delivery systems has become an integral part for the development and formulating of new medicines. So, research continuously keeps on searching for new ways to deliver drugs over a long period of time or for a well-controlle...

Open access Research Article 10.9734/JPRI/2017/34305

Development and Validation of New Analytical Method for the Determination of Particle Size Distribution of Metformin Hydrochloride Using Laser Based Particle Size Analyzer

Amit Gosar, Shivaji Folane, Sanjay Pawar, Mithun Gharat, Amit Lalge & Shivaji Jadhav · Journal of Pharmaceutical Research International · 2017

Metformin Hydrochloride has characteristic nature of lump formation and determination of particle size with reproducible result is difficult and particle size determination method is not reported in literature. Hence novel rugged and reproducible method has been developed for the...

Open access Research Article 10.9734/JPRI/2017/33911

Efficacy and Safety of Reimbursed Orphan Medicines in Bulgaria – Systematic Review and Meta-analysis (Part I)

Maria Kamusheva, Konstantin Mitov, Miglena Doneva, Assena Stoimenova, Maria Dimitrova & Guenka Petrova · Journal of Pharmaceutical Research International · 2017

Background: To make reimbursement decisions for orphan medicines the regulators need robust evidences for their efficacy and safety provided by systematic reviews and meta-analyses. The goal of the current study is to evaluate the efficacy and safety of orphan medicines included...

Open access Research Article 10.9734/JPRI/2017/34031

Neonatal Effects after Selective Serotonin Reuptake Inhibitors and Benzodiazepines Administration during Pregnancy

Georgios Eleftheriou, Fiocchi Roberto, Butera Raffaella, Giampreti Andrea, Mangili Giovanna & Molinaro Delfina · Journal of Pharmaceutical Research International · 2017

Aims: To evaluate whether the co-administration of benzodiazepines (BDZ) and selective serotonin and serotonin/norepinephrine reuptake inhibitors (SSRI/SNRI) during pregnancy is associated with an increased risk of abstinence symptoms in the newborns. Methods: Twenty six neonates...

Open access Research Article 10.9734/JPRI/2017/34620

A Model to Determine Effective Factors on Pharmacy Major Selection (A Case Study: Students of Zabol University of Medical Sciences)

Mahdi Eydi, Zahra Moradi, Reza Randian, Ali Rahdari & Amin Aliabadi · Journal of Pharmaceutical Research International · 2017

Background: Annually, a large number of students tend to study pharmacy. Students enthusiastically begin their studies; however, they lose their tendency over time. This study addresses motives and effective factors on pharmacy major selection as well as factors which discourage...

Open access Research Article 10.9734/JPRI/2017/31530

Cytotoxicity of Endocytosis and Efflux Inhibitors in the BeWo Cell Line

Mansi Shah, Luke Bourner, Shariq Ali, Sanaalarab Al-Enazy & Erik Rytting · Journal of Pharmaceutical Research International · 2017

Aims: The purpose of this study was to determine the cell viability and cytotoxicity of various endocytosis and efflux inhibitors which can be used to determine transport and uptake mechanisms in the BeWo (b30 clone) human placental trophoblast cell line. Ethanol and dimethylsulf...

Open access Research Article 10.9734/JPRI/2017/34606