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All published articles 175

Analyzing the Impact of Empowerment Model-based Education on Self-efficacy and Self-esteem of Patients with Diabetes

Nahid Dehghan, Shadi Abdollah Zargar & Simin Esmaeilpour Zanjani · Journal of Pharmaceutical Research International · 2018

Aims: Traditional education fails to effectively treat patients with chronic diseases.  Therefore, educating patients through a more comprehensive approach is required to encourage patients to actively participate in the management of the chronic disease. Empowering the patient i...

Open access Research Article 10.9734/JPRI/2018/40187

The Effect of Prone Position on Gastric Residuals in Preterm Infants

Golnaz Forough Ameri, Somayeh Rostami, Hamideh Baniasadi, Batoul Pour Aboli & Fereshteh Ghorbani · Journal of Pharmaceutical Research International · 2018

Background: Gastric residual is a common problem in preterm infants. Position after feeding affects the gastric residuals in preterm infants. This study aims to determine the effect of changing the infant's position on gastric residuals. Method: This study was conducted a cross-o...

Open access Research Article 10.9734/JPRI/2018/40433

Antioxidant Activity of Polyphenolic Leaf Extract from Santolina chamaecyparissus L. (Asteraceae) and the Isolated Luteolin-7-O-Glucoside

Chahra Boudoukha, Hamama Bouriche, Mahfuz Elmastas, Huseyin Aksit, Omer Kayir, Nusret Genc & Abderrahmane Senator · Journal of Pharmaceutical Research International · 2018

Aim: The present study aimed to investigate the chemical constituents and antioxidant potential of Santolina chamaecyparissus polyphenolic extract (SCPE). Materials and Methods: The extract containing phenolic compounds, was extracted with ethyl acetate and luteolin-7-O-glucoside...

Open access Research Article 10.9734/JPRI/2018/40726

Modulation of Nitrosamine-Induced Liver Injury in Rats by Propolis Extract: Long-term Study

Jehan A. Khan & Tahani M. Alghamdi · Journal of Pharmaceutical Research International · 2018

This study investigated the prophylactic effect of propolis extract against nitrosamine-induced liver injury in experimental animals. Eighty male adult rats were grouped into 8; control, treated with propolis extract, 3 groups treated with 0.1, 0.2, 0.5 mg nitrosamine/kg b.w and...

Open access Research Article 10.9734/JPRI/2018/41420

Physicochemical Characterization of a Liposomal Formulation Based on Glucosamine and Vitamin D, Commercialized as a Nutritional Supplement

German Madrigal Redondo, Rolando Vargas Zuñiga, Marianela Chavarría Rojas, Santiago Sibaja Rodríguez & Sindy Chaves Noguera · Journal of Pharmaceutical Research International · 2018

In the last years, the transport and release mechanism of bioactive compounds has been studied. The liposomes are multivesicular systems that enhance the absorption, stability, and transport of these compounds. The glucosamine is an amino-monosaccharide, it has been associated wi...

Open access Research Article 10.9734/JPRI/2018/39746

Biochemical and Toxicological Evaluation of Atorvastatin and Riboflavin in Diethylnitrosamine Induced Hepatocellular Carcinoma

Kaleemuddin Mohammed, Saida Sadath, Tariq Jamal, Syed Shoeb Razvi, Abdulaziz Al-Orabi, Ali H. Aseeri, Fahad A. Al-Abbasi & Firoz Anwar · Journal of Pharmaceutical Research International · 2018

Background: Atorvastatin, a commonly prescribed drug for the management of hyperlipidemia, acts as competitive inhibitors of HMG-CoA reductase—a rate-limiting enzyme in cholesterol synthesis. On the other hand, riboflavin is also a well-studied micronutrient known for its anti-pr...

Open access Research Article 10.9734/JPRI/2018/39652

Effect of Simvastatin, Hydrochlorothiazide and Combined Treatment on Bone Formation and Lipid Profile of Corticosteroid-Induced Osteoporosis in Albino Rats

Taha A. Kumosani, Mai A. Alim A. Sattar Ahmad, Mohamad Qari & Hanan Ali Amin · Journal of Pharmaceutical Research International · 2018

Statins and thiazides which are widely prescribed for the treatment of hyperlipidemia and hypertension play an important role in bone metabolism and may have potential therapeutic implications for osteoporosis.  Moreover, concomitant use of statins and thiazides may offer additiv...

Open access Research Article 10.9734/JPRI/2018/40943

Phytochemical Screening and Hypoglycemic Property of Globimetula braunii (Loranthaceae) Leaf Extracts

Gideon O. Okpanachi, Avosuahi R. Oyi, Hassan Musa, A. Abdulsamad, Muhammad B. Sani & Jamilu Ya’u · Journal of Pharmaceutical Research International · 2018

Aims: To carry out phytochemical screening, acute toxicity test and to investigate the hypoglycemic potential of the ethanol extract and fractions of Globimetula braunii leaves. Place and Duration of Study: Department of Pharmacognosy and Drug Development and Animal House, Depart...

Open access Research Article 10.9734/JPRI/2018/39870

Possible Gastroprotective Mechanisms of Dacryodes edulis Extract in Indomethacin-Induced Gastric Ulceration in Male Wistar Rats

E. Nwaonukuru, O. O. Olaniyi & F. S. Oluwole · Journal of Pharmaceutical Research International · 2018

African bush Pear known as is a well-known plant in West Africa, the fruits are edible while the bark, leaves, stem and roots are employed for a variety of purposes. It has been previously reported to possess high antioxidant properties and has also been used in folkloric medicin...

Open access Research Article 10.9734/JPRI/2018/36166

Cell Proliferation and Cytotoxic Studies of Vernonia amygdalina on Vascular Smooth Muscle Cells and HT 29 Cell Lines

Adegbolagun T. Adeoye, Ademola A. Oyagbemi, Temidayo O. Omobowale, Olusegun A. Fagbohun, Momoh A. Yakubu & Adeolu A. Adedapo · Journal of Pharmaceutical Research International · 2018

The antiproliferative effects of the methanol leaf extracts of Vernonia amygdalina (V. amygdalina) Del (Asteraceae) on Vascular Smooth Muscle Cells (VSMC) and Human Colorectal Adenocarcinoma Cell line (HT 29) were investigated using the Cell Titer 96 MTT Proliferation Assay where...

Open access Research Article 10.9734/JPRI/2018/39496

The Neglected Anticancer Phytoceutical Treasures from the Nilgiris Biosphere: A Short Review

M. V. N. L. Chaitanya & P. Suresh · Journal of Pharmaceutical Research International · 2018

Background: Cancer is the second most dreadful disease of the globe and nearly 100 different types of cancer have been identified. The main problem with the cancer is its resistance and many existed synthetic molecules are becoming clinically insignificant on exposure to cancer c...

Open access Research Article 10.9734/JPRI/2018/40529

Isolation and Identification of Bacterial Strains Able to Biopolymer Polyhydroxybutyrate (Phb) Production from Soil of Al-Kharj Probes, Saudi Arabia

Gamal A. Gabr · Journal of Pharmaceutical Research International · 2018

Polyhydroxyalkanoates (PHAs), which is produced by several bacteria, is a biodegradable polymer that has many industrial and medical applications such as heart valves, scaffold, suture and drug delivery. The aim of the present study is to isolate and identify the bacteria produci...

Open access Research Article 10.9734/JPRI/2018/39532

On the Side Effects of ‘Pain’ and ‘Dehydration’ in the Top 20 Selling Pharmaceuticals of 2017

Paul A. Oakley · Journal of Pharmaceutical Research International · 2018

Aims: To critically review the potential side effects relating to pain and dehydration symptoms from the top 20 selling pharmaceuticals. Methodology: The Physicians’ Desk Reference medication guide and drugs.com website was used to review medication side effects. The categories o...

Open access Research Article 10.9734/JPRI/2018/39544

Isolation and Characterisation of a Soil Microbial Streptomyces Strain that Produces Membrane-Active Antimicrobial Metabolites

Parisa Azerang, Parviz Owlia, Vahid Khalaj, Farzad Kobarfard & Soroush Sardari · Journal of Pharmaceutical Research International · 2018

In continuation of our previous research, more than 60 microbial strains that were isolated from soil samples collected from desert, farming and mineral regions of Iran and sixteen isolated strains that produced antimicrobial metabolites were found to be effective against Escheri...

Open access Research Article 10.9734/JPRI/2018/39144

Inverse Regulation of Mir Let-7g and HMGA2 Gene in HPV-Infected and Not Infected Cervical Cancer Patients

Fatemeh Barazandeh, Khadijeh Onsory & Anahita Mohseni Meybodi · Journal of Pharmaceutical Research International · 2018

Introduction: Cervical cancer is the fourth most common neoplasm among women worldwide, with the majority of cases occurring in developing countries. High-risk human papilloma viruses (HPVs) types are accounted for more than 90% of cervical carcinomas. Despite standard treatment...

Open access Research Article 10.9734/JPRI/2018/34725