The selective phosphodiesterase 4 D enzymes play a crucial role in regulating signaling through the cyclic adenosinmonophosphate second messenger system by hydrolyzing cyclic nucleotides. The PDE4 gene family includes four subtypes, PDE4A-D, distinguished by the presence of conse...
Open access
Research Article10.9734/ajpr/2024/v14i7359
Rachida Chehrastane, Ihssan Hadj Hsain, Fatima Chait, Sanae Jellal, Hafsa Elouazzani, Nadia Cherradi, Nazik Allali, Latifa Chat & Siham El Haddad·Asian Journal of Pediatric Research·2024
Rhabdomyosarcomas is a soft tissue tumor with a highly invasive malignant cells that originate of the skeletal muscle cells, specially occurs in the head and neck regions, the presentation in the parameningeal region, including the paranasal sinuses and nasal cavity, the presenta...
Open access
Research Article10.9734/ajpr/2024/v14i6358
Objective: To examine expert perspectives on the prescription practices and clinical uses of paracetamol for managing pediatric febrile illness in routine Indian healthcare settings. Methods: The study utilized multiple-response questionnaires distributed electronically to clinic...
Open access
Research Article10.9734/ajpr/2024/v14i6357
Hutchinson-Gilford-Progeria syndrome (HGPS) cannot, to date, be treated causally. Therapy for affected children focus on alleviating the symptoms, treating secondary diseases and preventing complications such as strokes or heart attacks. Various medications and physiotherapeutic...
Open access
Research Article10.9734/ajpr/2024/v14i6355
Background: Near precise weight assessment among sick pediatric patients remains a dilemma and conventionally accepted weight assessment methods, in busy ED might be inaccurate or unreliable. Children have different weights at different ages, and accurate/precise weight measureme...
Open access
Research Article10.9734/ajpr/2024/v14i6356
Background: Neonatal Jaundice is a major contributing cause of newborn hospitalizations and a major cause of newborn mortality. It should not be a major cause of mortality even in developing countries Inadequate knowledge of mothers about NNJ results in delayed decision-making to...
Open access
Research Article10.9734/ajpr/2024/v14i6354
Autoimmune pancreatitis (AIP) has gained significant attention in recent years, with a notable increase in diagnoses due to the diagnostic utility of immunoglobulin G4 (IgG4). Despite the well-known IgG4-related type 1 AIP, a less recognized subtype known as type 2 AIP exists, wh...
Open access
Research Article10.9734/ajpr/2024/v14i6353
Background: Paracetamol is a medication that is often procured over the counter in many nations including Nigeria. It is therefore prone to abuse/misuse with consequences. Objective of the Study: To determine the prevalence of pre-hospital use of paracetamol, preferred formulatio...
Open access
Research Article10.9734/ajpr/2024/v14i6352
Background: Sleep plays a crucial role in maintaining the health and well-being of children, affecting their physical, psychological, and cognitive development. However, research has shown that sleep problems in children are increasingly prevalent, impacting their health and qual...
Open access
Research Article10.9734/ajpr/2024/v14i6351
We present a case involving an immunocompetent infant diagnosed with miliary tuberculosis complicated by macrophage activation syndrome. Macrophage activation syndrome (MAS), also known as bone marrow hemophagocytosis, presents as a non-specific clinical condition characterized b...
Open access
Research Article10.9734/ajpr/2024/v14i6349
Sickle cell disease encompasses diseases that are pathophysiologically caused by hemoglobin S. The HbS component of total hemoglobin in SCD is normally over 50%. HbS is based on an amino acid substitution at position 6 of the β-globin chain, where glutamic acid is replaced by val...
Open access
Research Article10.9734/ajpr/2024/v14i6350
Sandhoff disease is a rare inherited disorder within the sphingolipidosis family, characterized by the accumulation of lipids in the nervous system due to a deficiency in hexosaminidase types A and B enzymes. This condition leads to progressive neurological disorders and eventual...
Open access
Research Article10.9734/ajpr/2024/v14i5348
Allgrove syndrome, or Triple A syndrome, is a very rare autosomal recessive disorder with three key clinical features: achalasia, alacrima, and adrenal insufficiency. Around a third of patients present with additional features, such as neurological and autonomic manifestations (m...
Open access
Research Article10.9734/ajpr/2024/v14i5347
Parents who overschedule their children, put a lot of pressure on them to succeed academically, and want them to act and behave like tiny adults beyond their mental, social, or emotional capabilities are considered to be suffering from the disease known as "hurried child syndrome...
Open access
Research Article10.9734/ajpr/2024/v14i5346
Joaquim Pinto, Yenny Puspitasari, Yuli Periostiwati, Carlos Boavida Tilman, Adelina Pinto & Estevao Menezes Ximenes·Asian Journal of Pediatric Research·2024
Background: Integrated Management of Childhood Illness (IMCI) is needed to address infant mortality in sub-Saharan African and South Asian countries of 11 million cases, due to diarrheal diseases, pneumonia, measles, malnutrition and newborn care problems. (IMCI) is an approach t...
Open access
Research Article10.9734/ajpr/2024/v14i5345