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All published articles 521

Theoretical Investigation into the Change in the Number of Water Molecules in Solvent Inaccessible Region of an Enzyme and Enzyme-substrate Complex

Ikechukwu Iloh Udema & Abraham Olalere Onigbinde · Asian Journal of Research in Biochemistry · 2019

Background: There may be dry enzymes, but water remains indispensable for the catalytic action of enzymes. There is not as much interest in how the presence of a drug such as aspirin and a psychoactive compound such as ethanol may affect the water-mediated role of the enzyme. Obj...

Open access Research Article 10.9734/ajrb/2019/v5i230085

Haematopoietic Potential of Ethanolic Leaf Extract of Talinum triangulare in Wistar Rats

A. I. Airaodion, E. O. Ogbuagu, J. A. Ekenjoku, U. Ogbuagu & E. O. Airaodion · Asian Journal of Research in Biochemistry · 2019

Aim: This study focuses on assessing the haematopoietic potential of ethanolic extract of Talinum triangulare leaves in Wistar rats. Methods: Fresh plants of T. triangulare were purchased from a local market in Orita-Challenge area of Ibadan, Nigeria. They were air dried at room...

Open access Research Article 10.9734/ajrb/2019/v5i230084

Biochemical and Histological Changes Associated with Azo Food Dye (Tartrazine) in Male Albino Rats

Ibioku Elekima, Ogechi Edna Nwachuku, Damion Ukwukwu, Harrison Ugo Nwanjo & Nsirim Nduka · Asian Journal of Research in Biochemistry · 2019

Aim: To study the effect of chronic exposure of tartarzine at ADI doses on some biochemical parameters of male albino rats. Study Design: The design involved chronic study. In the study, the experiment was divided into phase 1, 2, and 3 which lasted for 30, 60 and 90 days respect...

Open access Research Article 10.9734/ajrb/2019/v5i130083

In-vivo Study on Organometallic Compounds as Anticancer Agents

F. Z. Mohammed, Elsherbiny H. Elsayed, Atef E. Abd Elbaky & H. M. Shalaby · Asian Journal of Research in Biochemistry · 2019

This study aims to study the in-vivo anticancer effect of the synthesized copper complexes of 2,3-dihydroxy benzaldehyde thiosemicarbazone (3a,b), followed by evaluating their antioxidant activity.  Materials and methods: A total number of 80 adult female swiss albino mice weighi...

Open access Research Article 10.9734/ajrb/2019/v5i130082

In-vitro Biochemical Studies on Organometallic Compounds as Anticancer Agents

F. Z. Mohammed, Elsherbiny H. Elsayed, Atef E. Abd Elbaky & H. M. Shalaby · Asian Journal of Research in Biochemistry · 2019

This study aims to synthesis of copper complexes of 2,3-dihydroxy benzaldehyde thiosemicarbazone (3a,b), followed by evaluating their in vitro anticancer properties. The prepared compounds have been also evaluated for their ability to induce apoptosis. A total number of 80 adult...

Open access Research Article 10.9734/ajrb/2019/v5i130080

Examination of Conditions for Optimized Decellularized Liver Preparation

Jaeyong Cho, Yukako Fukuda, Nana Shirakigawa & Hiroyuki Ijima · Asian Journal of Research in Biochemistry · 2019

Aims: The main aim of our study was to examine the concentration of surfactant that can cause significant disruption of the resulting decellularized liver structure. Furthermore, it is our goal to determine the suitable solvent that can boost the potential of each surfactant. Met...

Open access Research Article 10.9734/ajrb/2019/v5i130079

Qualitative and Quantitative Phytochemical Screening, Antioxidant and Anti-inflammatory Activities of Acetone Extract of Brassica juncea L. Leaf

Pratima Khandayataray & Meesala Krishna Murthy · Asian Journal of Research in Biochemistry · 2019

Objective: The aim of this study is to evaluate the phytochemical screening; antioxidant and antiinflammatory activity of acetone extract of Brassica juncea (L.) Czern leaf. Methods: Qualitative and quantitative phytochemical screening was conducted by following standard protocol...

Open access Research Article 10.9734/ajrb/2019/v5i130078

Toxicity Impact on Bioaccumulation of Potentially Toxic Elements in African Giant Land Snail (Archachatina margenata) Treated with Different Soils and Its Ecological Risk Assessment

Oguh C. Egwu, Ugwu C. Victor, Uzoefuna C. Casmir, Usman Sa’adat, Nkwocha C. Chibueze & Amanabo Musa · Asian Journal of Research in Biochemistry · 2019

This study investigated the concentrations of heavy metals (As, Cd, Cr, Cu, Hg and Pb) in African Giant Land Snail (AGLS) treated with different soil samples dumpsite (A), mining site (B) and control soil (C) (a reserve area where no activities) use in farming AGLS and also to as...

Open access Research Article 10.9734/ajrb/2019/v4i430077

Combined Antioxidant Recovery Properties of Fruit Juice Extracts of Cucumber and Water Melon on Lipid Profile and Gonadal Steroid Levels of Cadmium Induced Testicular Damage on Male Albino Rats

F. C. Anacletus, B. Nwakaku & K. T. Nwauche · Asian Journal of Research in Biochemistry · 2019

The antioxidant protective effects of fruit juice of cucumber and watermelon on lipid profile of cadmium induced toxicity on male albino rats was investigated. Forty male rats were divided into eight groups. Group NC served as normal control group while group PC was positive cont...

Open access Research Article 10.9734/ajrb/2019/v4i430076

Antifungal Action of Garlic (Allium sativum) and Ginger (Zingiber officinale) on Some Pathogenic Fungi

V. N. Agi & C. A. Azike · Asian Journal of Research in Biochemistry · 2019

Background: The antifungal activities of fresh garlic (Allium sativum) and ginger (Zingiber officinale) on the growth of three known pathogenic fungi were investigated. The test organisms were Aspergillus spp Penicillium spp and Candida albicans. Methodology: Two different concen...

Open access Research Article 10.9734/ajrb/2019/v4i430075

Biochemical Indices and Haematological Studies of Ethyl Acetate Extract of Persea americana Leaf in Albino Rats

J. A. Mashi, A. M. Sa’id, F. Bello, H. M. Yakasai, B. Bello & R. I. Idris · Asian Journal of Research in Biochemistry · 2019

The aim of this present study was to evaluate the effect of ethyl acetate extract of P. americana (avocado) on liver and kidney function, lipid profile as well as haematological parameters in albino rats. A total of 20 albino rats were used for this experiment and they were divid...

Open access Research Article 10.9734/ajrb/2019/v4i430074

Biochemical Parameters, Activity Levels of Marker Enzymes and Serum Electolytes of Wistar Albino Rats Fed Mango (Mangifera indica) Pulp Formulated Diets

Pauline N. Iheagwam, Eugene N. Onyeike & Benjamin A. Amadi · Asian Journal of Research in Biochemistry · 2019

Biochemical parameters, activity levels of marker enzymes and serum electrolytes of Wistar albino rats fed naturally ripe (control), unripe and artificially ripened mango pulp formulated diets were investigated. Ripe and unripe fruits were collected and used for the study and art...

Open access Research Article 10.9734/ajrb/2019/v4i330072

Effect of Oral Intake of African Locust Bean on Fasting Blood Sugar and Lipid Profile of Albino Rats

Augustine I. Airaodion, Edith O. Airaodion, Emmanuel O. Ogbuagu, Uloaku Ogbuagu & Etinosa U. Osemwowa · Asian Journal of Research in Biochemistry · 2019

Background: African locust bean is a condiment believed to be for the people of low class. Its health importance has not been fully known especially to the so-called high class. Aim: This study is aimed at investigating the effect of African locust bean on fasting blood sugar and...

Open access Research Article 10.9734/ajrb/2019/v4i430073

Effects of ‘ZPC’ Polyherbal Formulation on Diabetic-Dyslipidemic Wistar Rats

Agatemor Uzuazokaro Mark- Maria, Ozioko Eucharia Ngozi, Momoh Theophilus Boniface, Idakwoji Precious Adejoh & Nweje- Anyalowu Paul Chukwuemeka · Asian Journal of Research in Biochemistry · 2019

In this study the antidiabetic effect of a polyherbal formulation- ZPC was investigated in Wistar rats. Diabetes was induced by intraperitoneal injection of streptozotocin at a dose of 50 mg/kg. Rats having Fasting Blood Sugar (FBS) level above 250 mg/dl after 72 hrs were conside...

Open access Research Article 10.9734/ajrb/2019/v4i330071

Synthesis, Characterization and Cytotoxic Activity of N-(5-indanyl(methylene)anthranilic acid(5-indanyl methylene)-hydrazide and Its Pt(II) Complex

Nasser Mohammed Hosny & Lamiaa A. A. Barakat · Asian Journal of Research in Biochemistry · 2019

Since the discovery of the platinum based complex, cisplatin, medicinal inorganic chemistry has attracted much more attention and a large number of platinum complexes with promising pharmacological properties have been synthesized. In this work a new platinum complex of N-(5-inda...

Open access Research Article 10.9734/ajrb/2019/v4i330070