Immune-mediated diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), multiple sclerosis (MS) and Inflammatory Bowel Disease (IBD: Crohn's Disease & Ulcerative Colitis) represent a significant global health burden characterized by a loss of immune...
Open access
Research Article10.9734/aji/2025/v8i1174
Hacene Meriche, Sara Zaghez, Feriel Sandra Bouafia, Boutheina Abdaoui, Nacima Sabiha Gadiri & Hichem Frigaa·Asian Journal of Immunology·2025
Multiple myeloma (MM) in pregnant women is a rare disease characterized by clonal proliferation of plasma cells producing monoclonal immunoglobulin, which suppresses the normal production of other antibodies and weakens the maternal immune response. Plasma cells release inflammat...
Open access
Research Article10.9734/aji/2025/v8i1173
Background: Non-IgE-mediated food protein-induced gastrointestinal allergies (FPI-GIAs) are poorly understood, although IgE-mediated hypersensitivities have been extensively described. Patients with poultry meat allergy may present several phenotypes regarding clinical presentati...
Open access
Research Article10.9734/aji/2025/v8i1172
Godiya Peter Mamman, Caleb Ndako Angulu, Aminu, Ado, Mohammed Evuti Mahmud, Ruqayyatu Aliyu, Samuel Angulu & Adeoye Daniel Owoyale·Asian Journal of Immunology·2025
The field of metabolomics involves the high-throughput identification and measurement of all endogenous and exogenous low-molecular-weight (<1kDa) small molecules or metabolites in a biological system by analyzing the metabolome in cells, biofluids, tissues, or organisms. Meta...
Open access
Research Article10.9734/aji/2025/v8i1171
Background: Immune tolerance is established between the foetus and the mother in normal pregnancies. However, this tolerance may be breached, resulting in undesired pregnancy outcomes such as spontaneous abortion, foetal anomalies, and maternal complications. Reported studies sug...
Open access
Research Article10.9734/aji/2025/v8i1170
Background: The cat-pork syndrome and the cross-reactivity between cat dander and dog dander are particular situations associated with the allergic multimorbidity phenotypes. The perception of this cross-reactivity must benefit the allergist dealing with these conditions. Aim: To...
Open access
Research Article10.9734/aji/2025/v8i1168
Background: Panallergens, such as tropomyosin, produce cross-reactivity between indoor allergens and food allergens, including the house dust mite Blomia tropicalis and the Brazilian pink shrimp Farfantepenaeus brasiliensis, and are responsible for the clinical symptoms present i...
Open access
Research Article10.9734/aji/2025/v8i1169
Post-operative wound infections (POWIs), sometimes referred to as post-surgical wound infections (PSWIs), are a common complication following surgery. Surgeries frequently elicit a variety of immunological responses subsequent to tissue damage and incision which may hinder wound...
Open access
Research Article10.9734/aji/2025/v8i1167
Monocytes and macrophages play a pivotal role in the pathogenesis of HIV infection, contributing not only to viral persistence but also to the development of non-AIDS-defining events (nADEs) in People Living with HIV (PLWH). These innate immune cells act as long-lived viral reser...
Open access
Research Article10.9734/aji/2025/v8i1166
Inflammatory bowel diseases (IBD) are increasingly common pathologies, affecting both adults and children. This study investigates the clinical and epidemiological characteristics of IBD among patients at the gastroentero-hepatology department of Annaba University Hospital. Condu...
Open access
Research Article10.9734/aji/2025/v8i1165
Okolie Lucy Janefrancis, Maduka Amuche Stella, Ojeniran Taiwo Paul, Yahaya Imran Umar, Lawal Mustapha, Oniye Mariam Masud & Umar Muhammad Muhsin·Asian Journal of Immunology·2025
Trained immunity, a concept introduced more than a decade ago, defines the non-specific memory capacity of innate immunity by epigenetic and metabolic reprogramming. It involves features of epigenetic and metabolic reprogramming of innate immune cells that induce long-term functi...
Open access
Research Article10.9734/aji/2025/v8i1163
Immune mediated diseases and syndromes are rare and attributed at most to genetic and environmental interactions. Macrophagic Myofasciitis MMF is one of these syndromes sub-entities. In the present opinion the immunobiology of MMF was being reviewed. The molecular autoimmune mech...
Open access
Research Article10.9734/aji/2025/v8i1164
Anti-N antibodies usually possess cold-reactive properties which make them clinically insignificant and are mostly classified as naturally occurring IgM antibodies. These antibodies sometimes trigger reactions at body temperature (37°C) or in the anti-human globulin phase resulti...
Open access
Research Article10.9734/aji/2025/v8i1162
Background: Several publications report that formaldehyde is responsible for hypersensitivity reactions in patients with contact dermatitis, as diagnosed by "in vivo" provocation tests. There is no standardized lab exam that can endotype the mechanisms responsible for these pheno...
Open access
Research Article10.9734/aji/2025/v8i1161
The aim of the study was to determine the prevalence of myocardial and circulatory complications among lupus patients, such as pericarditis, heart failure, endocarditis, ventricular dysfunction, and Myocarditis. It was also to assess the association of lupus with increased myocar...
Open access
Research Article10.9734/aji/2025/v8i1160