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Methods of Immunohistochemistry and Its Applications: A Review

Kaine, Omashim Oluwakemi & Odokuma, Igho Emmanuel · Asian Journal of Medical Principles and Clinical Practice · 2025

Hematoxylin and Eosin stain is a standard stain in histopathology that allows for the microscopic analysis of tissue samples for the detection of infections and malignancies. However, problems arise due to the similar appearances of diseases and cells, leading the relevance of Im...

Open access Research Article 10.9734/ajmpcp/2025/v8i2357

Association Between Propranolol Use and Suicidal Ideation in Patients with Coronary Artery Disease: A Retrospective Cohort Study

Jiwon Kim & Eduardo Espiridion · Asian Journal of Medical Principles and Clinical Practice · 2025

Objective: To examine through large-scale hospital data analysis whether propranolol use, compared to losartan use, is associated with an increased incidence of suicidal ideation in patients with coronary artery disease (CAD). Methods: Our retrospective cohort study was performed...

Open access Research Article 10.9734/ajmpcp/2025/v8i2356

A Comparative Study on Spinal Versus General Anesthesia for Laparoscopic Cholecystectomy

Mohammad Rajibul Hasan, Tahmina Sharmin, Suttam Kumar Biswas & Md Badrul Isam · Asian Journal of Medical Principles and Clinical Practice · 2025

Background: Laparoscopic cholecystectomy (LC) is the gold standard for symptomatic cholelithiasis. While general anesthesia (GA) is conventionally used, spinal anesthesia (SA) is emerging as a viable alternative, potentially offering advantages in a resource-constrained setting....

Open access Research Article 10.9734/ajmpcp/2025/v8i2355

Optimizing Computer-Aided Detection for Tuberculosis (CAD4TB) Thresholds for Community TB Screening in Nigeria: Recalibrating Threshold with Local Data

Odume Bethrand, Inumanye N. Ojule, Emmanuel Etim Clement, Daniel Okon, Best Ordinioha & Elias Aniwada · Asian Journal of Medical Principles and Clinical Practice · 2025

Background: Computer-aided detection (CAD) is a promising tool for tuberculosis (TB) screening, but its performance, particularly the optimal abnormality score thresholds, is highly context-specific. This study aimed to optimise the use of computer-aided detection (CAD4TB) softwa...

Open access Research Article 10.9734/ajmpcp/2025/v8i2354

Antimicrobial Resistance and Detection of Panton-Valentine Leukocidin Gene in Staphylococcus aureus from Clinical Samples in Federal Medical Centre, Keffi, Nigeria

Nkene, I. H, Zakka, K. T, Bolarinwa, O. F, Ngwai, Y. B, Usman, T. F, Galleh, R. P, Asogwa, I. S, Igbawua, I. N, Fagbola, O.F, Akpotu, M. O, Tama, S. C, Abimiku, R. H, Abdulmumin, R. I & Simon, O. A · Asian Journal of Medical Principles and Clinical Practice · 2025

Aims: This study investigated antimicrobial resistance and detection of Panton-Valentine Leukocidin gene in S. aureus from clinical samples in Federal Medical Centre, Keffi, Nigeria. Study Design:  Cross sectional study. Place and Duration of Study: Department of Microbiology, Fe...

Open access Research Article 10.9734/ajmpcp/2025/v8i2353

Evaluation of Telemedicine Services in the Nigerian Air Force: Structure, Operations, and Utilization Patterns

Osagie Kenneth Cole, Ogaji, Daprim Samuel, Daniel Ekpah & Emmanuel Etim Clement · Asian Journal of Medical Principles and Clinical Practice · 2025

Telemedicine presents a promising opportunity to enhance healthcare delivery, particularly for military personnel who often face unique challenges in accessing in-person medical care. In the Nigerian Air Force (NAF), telemedicine services have been introduced in three pilot forma...

Open access Research Article 10.9734/ajmpcp/2025/v8i2352

Trichobezoar Revealing Schizophrenia in an Adolescent: A Case Report

Haifa Mami, Hela Bouzouaya, Feten Sbai, Fériel Bouagina, Sirine Hjaij, Sami Mahfoudhi & Mohamed Ali Sbai · Asian Journal of Medical Principles and Clinical Practice · 2025

Introduction: Trichotillomania, often considered an impulse control disorder, can sometimes conceal a more severe underlying psychiatric condition. We report the case of an adolescent initially hospitalized for a trichobezoar, revealing a progressive psychotic disorder. Clinical...

Open access Research Article 10.9734/ajmpcp/2025/v8i2349

Autoimmune Hemolytic Anemia Revealing Sarcoidosis: A Case Report

Tounsi Haifa, Bouzouaya Hela, Feten Sbai, Hamdi Mohamed Salah, Ghachem Ikbel, Sbaihi Siwar, Amri Raja & Sbai Mohamed Ali · Asian Journal of Medical Principles and Clinical Practice · 2025

Hematological involvement in sarcoidosis is often characterized by lymphopenia and splenomegaly. However, auto-immune hemolytic anemia associated with sarcoidosis is scarcely reported. Herein, we report a novel case of this unusual clinical presentation. A 40-year-old female was...

Open access Research Article 10.9734/ajmpcp/2025/v8i2350

Assessment of Nutritional and Biochemical Profiling of Andrographis paniculata Ethanol Extract for Its Nutraceutical Value

Stanley Udochukwu Alugbuo, Friday Obinwa Uhegbu, Chidi Ijeoma Nosiri, Ogbanshi Moses Eji, Chibuike Valentine Edom, Amarachi Chidinma Chikezie, Bonaventure Amobi Odo, Finian Uchenna Okore, Felicity Otito Asogwa & Jennifer Chiazokam Edom · Asian Journal of Medical Principles and Clinical Practice · 2025

Background: Andrographis paniculata has long been used as traditional medicine in Asia. It’s also referred to as the "king of bitters or kalmegh," especially in the Chinese and Ayurvedic systems. Despite extensive research on the plant's nutritional makeup, which has been linked...

Open access Research Article 10.9734/ajmpcp/2025/v8i2351

Ergonomic Awareness and Preventive Practices of Muscoskeletal Disorders Among Academic Staff in Abia State University, Uturu, Nigeria

Uka-Kalu, Ezinne Chioma, Elekeh, Rosemary Ichita, EUSEBIUS IRENE K & UWAEME, THANKGOD C. · Asian Journal of Medical Principles and Clinical Practice · 2025

Background: Musculoskeletal disorders (MSDs) are a significant occupational health concern among academic professionals due to prolonged standing, sitting, repetitive tasks, and suboptimal workstation arrangements. Ergonomics, the science of designing the workplace to fit the use...

Open access Research Article 10.9734/ajmpcp/2025/v8i2348

Angular Craniometric Analysis of Anthropometric Variation in the Anioma Facial Angle

EnaohwoTaniyohwo Mamerhi, Okoro Ogheneyebrorue Godswill, Igben Onoriode Vincent-Junior, Egwunyenga Michael Oge & Owhefere Great Owhefere · Asian Journal of Medical Principles and Clinical Practice · 2025

Background: The facial angle, originally introduced by Petrus Camper as a descriptive index in comparative anatomy and art, was historically misappropriated by early evolutionists and anthropologists as a pseudo-scientific tool for racial classification and intellectual stratific...

Open access Research Article 10.9734/ajmpcp/2025/v8i2345

Changes in Markers of Metabolic Disorder among Patients with Prostate Cancer Attending Oncology Clinic at Federal University Teaching Hospital, Owerri

Mgbeosuru Benson, Nwanjo Harrison U., Nwadike Constance N., Nwachukwu Uchenna C., Gilbert Ifechukwu P., Oko Oluebube M., Mbarah Ifunanya E., Arinzechi Ekpereamaka G., Ogbuokiri Arnold C. & Imakwu Icha Innocent · Asian Journal of Medical Principles and Clinical Practice · 2025

Background: Prostate cancer stands as one of the most prevalent and clinically significant malignancies affecting aging males worldwide, with mounting evidence linking its onset and progression to profound molecular alterations characterized by chronic systemic multifactorial met...

Open access Research Article 10.9734/ajmpcp/2025/v8i2346

Prevalence of Gag Reflex among Patients of Different Prosthodontic Treatment Modalities

Gayathri Suresh & Senbagavalli · Asian Journal of Medical Principles and Clinical Practice · 2025

Background: Gag reflex is a common clinical challenge encountered during prosthodontic procedures. Its frequency and severity may vary with the type of prosthodontic modality and patient-related factors. The gag reflex is a protective neuromuscular response that prevents foreign...

Open access Research Article 10.9734/ajmpcp/2025/v8i2347

In-vitro Antioxidant and Metal Chelation Properties of Ginger, Garlic and Turmeric Extracts: A Nutraceutical Approach to Reducing Oxidative and Metal-Induced Stress

Joshua C. Ezema, Blessing T. Nwafor, John E. Udensi, Blessing C. Chiagorom, Chisom I. Obasi, Christiana I. Daniel, Winnie D. Olu, Ruth A. Francis, Vivian O. Ibekwe, Sunday C. Chukwudoruo, Kizito M.E. Iheanacho, Cosmas O. Ujowundu, Favour N. Ujowundu, Linus O. Agwu & Viola A. Onwuliri. · Asian Journal of Medical Principles and Clinical Practice · 2025

Heavy metal exposure and toxicity pose significant risks to human health, resulting in endocrine dysruption, oxidative stress, neurodegeneration and breakdown of the immune system. This study investigated the in vitro antioxidant and metal chelating capacity of combined extracts...

Open access Research Article 10.9734/ajmpcp/2025/v8i2343

Acetylcholinesterase and Butyrylcholinesterase Enzyme Inhibitory Activities of Ethanol Extract of Costus afer, Sida acuta and Irvingia gabonensis

Chioma Juliet Ejiofor, Adamma Angela Emejulu, Chieme Sunday Chukwudoruo, Chibuike Valentine Edom, Muhammad Tasi'u Uba, Okechukwu Franklyn Ohiagu, Chioma Irene Mbadugha & Hauwa Musa Hudu · Asian Journal of Medical Principles and Clinical Practice · 2025

Background: Scientific research in support of the use of various African plant species for the management of neurodegenerative diseases, including Alzheimer's disease (AD) is currently ongoing. Most of the approved drugs for the treatment of Alzheimer's disease have adverse effec...

Open access Research Article 10.9734/ajmpcp/2025/v8i2344