Hydrazide

A Reaction of N-Substituted Succinimides with Hydroxylamine as a Novel Approach to the Synthesis of Hydroxamic Acids

Bogdan A. Tretyakov, Svyatoslav Y. Gadomsky & Alexei A. Terentiev · Organics · 2023

We describe a novel two-step approach for the synthesis of compounds with a hydroxyl-amide group (hydroxamic acids), which are widely known for their biological activity (histone deacetylase inhibitors, matrix metalloproteinases inhibitors and others). The first stage is the synt...

Open access Research Article 10.3390/org4020015

Neighboring Nitrogen Atom-Induced Reactions of Azidoacetyl Hydrazides, including Unexpected Nitrogen-Nitrogen Bond Cleavage of the Hydrazide

Hiroki Tanimoto, Ryo Adachi, Aoi Otsuki & Takenori Tomohiro · Organics · 2022

We studied the hydrazide compounds of the α-azidoacetyl group, which showed specific click reactivity by the intramolecular hydrogen bonding between the azido group and the N-H of the hydrazide moiety. In the competitive click reactions with a general alkyl azide, both traceless...

Open access Research Article 10.3390/org3040035