Evaluation of the Clastogenicity of SJG-136, A Novel Pyrrolobenzodiazepine DNA Interstrand Cross-linking Agent, in Comparison with Nitrogen Mustard (HN2)
F. A. Delmani, J. A. Hartley & D. E. Thurston · Annual Research & Review in Biology · 2015
Aims: SJG-136 is a new pyrrolobenzodiazepine used as an anticancer drug with high cytotoxicity against a panel of cancer cells and proved to produce interstrand crosslinks in the minor groove of DNA. Methodology: In this work, SJG-136 (SG2000) was tested for its clastogenicity by...
Open access
Research Article
10.9734/ARRB/2015/19648