Pharmacokinetics

An In-silico Pharmacokinetics Study on Cis-Heptadeca-1,9-Diene-4,6-Diyne-3,8-Diol: A Nutraceutical Compound with Anticancer Properties

Paul Tobechukwu Okoli, Vivian Chiadikaobi Nzute, Olanrewaju Ayodeji Durojaye, Ogechukwu Henrietta Chielo, Queensley Chinyere Ajibo, Solomon Imaga Udo & Sandra Munachiso Ezeh · Asian Food Science Journal · 2019

The polyacetylenic compound cis-heptadeca-1,9-diene-4,6-diyne-3,8-diol with the trivial name of falcarindiol, has been shown through various studies to exhibit anticancer activities. The beneficial effects of polyacetylenes occur at nontoxic concentrations and thus represent phar...

Open access Research Article 10.9734/afsj/2019/v7i329972

Drug Metabolism and Disposition in Australian Marsupial Koala (Phascolarctos cinereus)

Suong N. T. Ngo & Anna C. Schumann · Annual Research & Review in Biology · 2018

Aims: Koalas are unique obligated eucalyptus feeding Australian marsupials that often require medical treatments after wildlife rehabilitation across Australia. At present, little is known about the pharmacology and pharmacokinetics of drugs commonly used in koalas and how koalas...

Open access Research Article 10.9734/ARRB/2018/43806

Development and Validation of Bio Analytical Method for Estimation of Bortezomib in k3 EDTA Human Plasma Using HPLC-ESI-MS/MS and Its Application to a Bioequivalence & CME Studies

Ravi Pulla, K Prakash, U Abhini, B Maheswari, V Divya, M Shushmitha & V Ravali · British Journal of Pharmaceutical Research · 2016

Purpose: To develop a highly selective, reproducible & precise rugged bio analytical method for estimation of Bortezomib (BTZ), “A Protease Inhibitor” in human plasma by validating the developed method in accordance to US-FDA guidelines. Methodology Envisaged: BTZ D3 was used as...

Open access Research Article 10.9734/bjpr/2016/30565