Six secondary amine derivatives derived from salicylaldehyde (SA) were successfully synthesized in good to excellent yields and evaluated for their biological activities. The synthesized compounds exhibited remarkable antioxidant properties, as determined by ABTS and phenanthroli...
Heterocyclic compounds are the cornerstone for active pharmaceutical ingredients. Among heterocycles, isoindoline core occupies a special place, as ten commercial bioactive compounds/drugs contain this skeleton decorated with several functional groups required for optimal recepto...
Marija Popović-Nikolić, Gordana Popović, Slavica Oljačić & Katarina Nikolić·Organics·2025
The acid–base equilibria of cetirizine were investigated with and without the presence of differently charged micelle-forming surfactants (anionic, cationic, nonionic). The pKa values were potentiometrically determined at 25 °C and at a constant ionic strength (0.1 M NaCl). Exper...
Alexandria Montavon, M. Raquel Marchán-Rivadeneira & Yong Han·Organics·2024
Natural products have been a reliable source of drug compounds in medical research. Technological advances have led to the discovery and characterization of many compounds that were previously difficult to isolate. However, when searching for anticancer drugs, finding natural com...
J. P. Mbula, E. M. Kitete, N. G. Kasiama, E. M. Ngoyi, J. T. K. Kwembe, D. D. Tshilanda, K. N. Ngbolua, D. S. T. Tshibangu, S. O. Mihigo, O. Onautshu & P. T. Mpiana·Archives of Current Research International·2022
Aim: Zanthoxylum gilletii is used in traditional medicine against several pains, namely urinary tract infections, malaria, lombargy, high blood pressure etc. Thus, the aim of this study was to review the literature on the traditionnal use, the phytochemical composition and the bi...
Open access
Research Article10.9734/acri/2022/v22i7537
Enzymes are biomolecules with highly specialized catalytic functions produced by all living organisms and are responsible for biochemical reactions in plants, animals, microorganisms and human beings. Nowadays enzymes are considered as core of biotechnology because they are the m...
Open access
Research Article10.9734/mrji/2019/v27i230093
Aims: To profile and address matters surrounding ochnaflavone (1), derivatives and analogues. Methodology: Papers concerning ochnaflavone, derivatives and analogues were accessed from search engines such as google scholar and pubmed. Results: Ochnaflavone and derivatives are comp...
Open access
Research Article10.9734/ACRI/2018/43042
The aqueous distillate (arka) of Boerhaavia diffusa was prepared and investigated qualitatively for TLC. The following work constitutes the enrichment of constituents present in the aqueous distillate (arka) by partition technique using various solvents such as toluene and ethyl...
Open access
Research Article10.9734/bjpr/2016/19399
Background: In addition to the problems of resistance to commonly used antibiotics, toxicity depicts the state of adverse effects caused by the interaction of toxicants with cells. Similarly, blood components are exposed to significant concentrations of toxic compounds as they fo...
Open access
Research Article10.9734/bjpr/2016/19971
The aim of this work was to find an alternative to chemical fungicides currently used in the control and prevention of activities of toxigenic Aspergillus flavus, A. parasiticus and A. ochraceus in food and feed. The antifungal activity of extracts of five medicinal plants used in...
Open access
Research Article10.9734/bjpr/2016/20390
Aim: This study was designed to evaluate the possible modulatory effect of vitamine E on tacrolimus (FK506)-induced renal injury in rats. Methods: Twenty-four male Wistar rats (6 animals in each group) were used in this study. The first group (Control) received normal saline intr...
Open access
Research Article10.9734/bjpr/2016/21684
Aim: A comparative evaluation of the physicochemical and in vitro dissolution properties of metformin hydrochloride tablet brands sampled in five cities in Ghana was undertaken to assess their pharmaceutical equivalence. Place and Duration of Study: Department of Pharmaceutics, K...
Open access
Research Article10.9734/bjpr/2016/21862
Aims: Highly Active Antiretroviral Therapy (HAART) is associated with metabolic complications. An unexpected extension of functional implications of melatonin, the neuro-hormone synthetized during the night, has been reported on the development of type 2 diabetes, sleep disturban...
Open access
Research Article10.9734/bjpr/2016/29474
Omeprazole (OPZ) efficiently suppresses acid secretion in the parietal cells of the stomach. It is widely recommended as proton pump inhibitor (PPI) in Egypt. Presence of many products containing omeprazole available in the Egyptian market raises questions of generic substitution...
Open access
Research Article10.9734/bjpr/2016/29952
Aim: Morus mesozygia is a specie of the Morus family in Africa that is traditionally used for the treatment of rheumatism. Until this moment, there is no available literature on the scientific evidence of the in vivo anti-inflammatory effects. The aim is to determine the safety o...
Open access
Research Article10.9734/bjpr/2016/28746