Pharmacophore

Synthesis of Antifungal Heterocycle-Containing Mannich Bases: A Comprehensive Review

Diego Quiroga & Ericsson Coy-Barrera · Organics · 2023

Mannich bases are a class of organic compounds usually obtained by the condensation reaction between an amine, a compound with active hydrogens, and an aldehyde. They are versatile intermediates in organic synthesis, and those compounds containing this motif find applications in...

Open access Research Article 10.3390/org4040035

Indole-Based Macrocyclization by Metal-Catalyzed Approaches

Subba Rao Cheekatla, Debashis Barik, Geethanjali Anand, Rakhi Mol K. M. & Mintu Porel · Organics · 2023

This review is dedicated to the different varieties of macrocycles synthesis bearing indole units in their architecture by metal-catalyzed strategies. The progress of the new macrocyclization approaches is persisted be a keen area of research. Macrocycles contain a wide variety o...

Open access Research Article 10.3390/org4030026