Determining Maximum Recommended Starting Dose (MRSD) in first in human (FIH) studies is a crucial milestone in the development path of a new pharmaceutical drug. It is imperative to determine what is the safe starting dose in these trials, as the drug would be introduced for test...
Brian Mark Churchill, Charu Gautam, Saket Ghaisas, Rashna Cama, Craig Davis, Bela Shah, Kiran Godse, Yogesh Marfatia, Ramesh Bhat, Sushil Pande & Sonja Vanwye·Asian Journal of Research in Dermatological Science·2022
Psoriasis is a non-communicable disease characterized by inflammation involving cutaneous T cells, dendritic cells, and keratinocytes. Release of cytokines leads to keratinocyte hyperproliferation and scaly plaques, and other manifestations of the disease including psoriatic arth...
Brian Mark Churchill, Pallavi Patri, Jula K. Inrig, Anju Gopan, Ekaterina Vorozheikina, Luis Mendoza, Lara Kristina Donato & Ruma Pal Ghosh·International Research Journal of Oncology·2021
With introduction of immunotherapy, the treatment of advanced renal cell carcinoma has undergone a substantial change. Immunotherapeutic agents including nivolumab, ipilimumab, pembrolizumab, have been introduced and approved for therapy of this life-threatening malignancy. Chime...
Tumor necrosis factor alpha (TNF-α), also called cachectin or cachexin, is a naturally occurring cytokine produced by activated macrophages and monocytes, and to a smaller scale by T-lymphocytes, B-lymphocytes, fibroblasts and astrocytes. It has both inflammatory and immunomodula...
Introduction: Chronic kidney disease (CKD) is associated with atherosclerosis, heart failure, valvular heart disease, arrhythmia, cardiovascular calcification, and sudden cardiac death. The calcification of the cardiovascular system increases as CKD progresses and is associated w...
Immunoglobulin A vasculitis (IgA Vasculitis), formerly called Henoch Schonlein Purpura (HSP) is a common systemic vasculitis in children. It is 33 times less common in adults than in children. Besides having dermatology manifestations in form of rash, it may affect other organs i...
Pantoprazone-Domperidone fixed-dose combinations are commonly used in End Stage Renal Disease (ESRD) patients on dialysis. The medication helps in control of drug induced gastritis that can occur due to several medications including oral calcium and iron supplements. Besides this...