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H. B. Akpan

Publications (8)

Histo-morphological Effects of Carica papaya on Cadmium Induced Prefrontal-Cortex Damage in Adult Wistar Rats

H. B. Akpan, O. D. Omotoso, E. Ogbonna, M. N. Negedu, S. A. Adelakun, F. E. Oladipupo, A. O. Adedeji, A. A. Akande, A. R. Olapade & P. K. Orisadiran · European Journal of Medicinal Plants · 2018

Background: This research investigated the recuperative (restorative) effect of aqueous extract of Carica papaya fruit on cadmium induced prefrontal-cortex damaged in adult Wistar rats (Rattus norvegicus). Previous research reports have confirmed that cadmium toxicity results in...

Open access Research Article 10.9734/EJMP/2018/16429

Antioxidant Properties of Carica papaya on Cadmium Toxicity on Prefrontal-Cortex of Adult Wistar Rats

H. B. Akpan, O. D. Omotoso, A. R. Olapade, E. Ogbonna, M. N. Negedu, A. A. Akande, A. O. Adedeji, F. E. Oladipupo & P. K. Orisadiran · European Journal of Medicinal Plants · 2018

Background: Cadmium is a carcinogenic agent in humans, and therefore, a cancer causing substance. In the body it is extensively circulated, but it is bound mainly to erythrocytes. Though cadmium binds to various macromolecules and proteins in the body, it is not well metabolized....

Open access Research Article 10.9734/EJMP/2018/22753

Recuperative Action of Aqueous Carica papaya Extract on Cadmium Induced Loss of Nissl Bodies in the Frontal Cortex

H. B. Akpan, O. D. Omotoso, E. Ogbonna, S. A. Adelakun, F. E. Oladipupo, A. A. Akande, P. K. Orisadiran & A. R. Olapade · Journal of Applied Life Sciences International · 2017

Background: Cadmium is a heavy metal that causes generation of free radicals that have been discovered to cause damage to cells and tissues in the body. This research work examined the damaging effects of cadmium, and the recuperative effect of Carica papaya aqueous extract to re...

Open access Research Article 10.9734/JALSI/2017/16430

Lipid Peroxidation is Key to Neuronal Cell Death in the Inferior Colliculus of STZ-Induced Diabetic Rats

H. B. Akpan, P. D. Shallie, A. K. Adefule & T. K. Adenowo · Journal of Applied Life Sciences International · 2017

Neuropathy is one prominent complication yet to be separated from diabetes mellitus and various mechanisms have been identified for this complication. In this study, lipid peroxidation was investigated as a possible neuropathic agent in the inferior colliculus (IC) of Streptozoto...

Open access Research Article 10.9734/JALSI/2017/26546

Assessment of the effect of Watermelon and Aloe Vera on Cadmium Induced Heart Damage in Adult Wistar Rats (Rattus novergicus)

O. D. Omotoso, S. A. Adelakun, H. B. Akpan, U. A. Yusuf, O. O. Adeleye & O. O. Adeyinka · Cardiology and Angiology: An International Journal · 2016

The aim of the study was to investigate the antioxidant property of watermelon and aloe vera against cadmium damaging effect on the heart and the packed cell volume of the blood. Thirty five Wistar rats were obtained and acclimatized for two weeks. They were randomly divided into...

Open access Research Article 10.9734/CA/2016/24272

Positive Anti-Cadmium Poisoning Anti-Oxidant Effects of Moringa Seed Oil and Cashew Nut Oil in Juvenile Wistar Rats Hippocampus

O. D. Omotoso, J. O. Owolabi, H. B. Akpan, B. J. Dare, E. A. Ashamu & S. A. Adelakun · Journal of Advances in Medical and Pharmaceutical Sciences · 2015

Moringa oleifera seed oil and Anacardium occidentale oil contain certain antioxidants including ascorbic acid, phenolics, flavonoids and carotenoids; these antioxidants have potentials to act against oxidative stress generated by cadmium accumulation and activities in tissues. Th...

Open access Research Article 10.9734/JAMPS/2016/16310

PAS Exfoliation in Watermelon and Aloe Vera Recuperate Glycogen in Heart Tissue Damaged by Cadmium in Adult Wistar Rats (Rattus novergicus)

O. D. Omotoso, S. A. Adelakun, N. O. Amedu, U. P. Idoko, I. S. Oji & H. B. Akpan · Cardiology and Angiology: An International Journal · 2016

Cadmium (Cd) is a major concern of World Health Organization for public health and is a highly toxic element which is naturally present in all parts of the environment. Watermelon contributes nutritional agents as antioxidants and some specific amino acid. Aloe vera plants contai...

Open access Research Article 10.9734/CA/2016/24273

Ameliorative Effects of Watermelon and Aloe vera against Cadmium Damage on the Histomorphology of the Heart Tissue of Adult Wistar Rats (Rattus novergicus)

O. D. Omotoso, S. A. Adelakun, N. O. Amedu, U. P. Idoko, I. S. Oji & H. B. Akpan · Cardiology and Angiology: An International Journal · 2016

Cadmium (Cd) is a toxic element that can produce reactive oxygen species. Fruits and vegetables are natural sources of various bioactive compounds. Watermelon contains nutritional agents like lycopene, citrulline and arginine and Aloe vera is used for therapeutic purposes. This s...

Open access Research Article 10.9734/CA/2016/24276