Mamadou Guy-Richard Koné

Theoretical Study of the Stability and Chemical Reactivity of a Series of Dihydropyrazoles with Antiproliferative Activities

Mamadou Guy-Richard Koné, Lamoussa Ouattara, Kouakou Nobel N’Guessan, Georges Stephane Dembele, Panaghiotis Karamanis & Nahossé Ziao · Chemical Science International Journal · 2024

In recent years, the number of cancer cases are increasing particularly that of prostate. In this work, we were interested in anticipating dihydropyrazole-cancer cell interactions and their anti-prostatic activity by studying the chemical reactivity and stability of a series of s...

Open access Research Article 10.9734/CSJI/2024/v33i6929

Modeling of a Series of Dihydropyrazole Derivatives with Antiproliferative Activity by Quantum Chemical Methods

Mamadou Guy-Richard Koné, Georges Stephane Dembele, Bafétigué Ouattara, Adama Niaré, N’nan Akau Amandine Kouamé, Panaghiotis Karamanis & Nahossé Ziao · Chemical Science International Journal · 2023

Cancer is any disease characterised by the rapid proliferation of abnormal cells in normal body tissue. Recent years have been marked by an increase in the number of cases of cancer, particularly that of the prostate. Cancer can affect any part of the body. Despite the efforts ma...

Open access Research Article 10.9734/CSJI/2023/v32i4852

Theoretical Study of the Chemical Reactivity of Five Schiff Bases Derived From Dapsone by the DFT Method

Jean Stéphane N’dri, Mamadou Guy-Richard Koné, Charles Guillaume Kodjo, Ahmont Landry Claude kablan, Sopi Thomas Affi, Lamoussa Ouattara & Nahossé Ziao · Chemical Science International Journal · 2018

This theoretical study of chemical reactivity was conducted using the method of the Density Functional Theory (DFT), with B3LYP/6-311G (d, p) as calculation level. A series of five (05) Schiff bases derived from 4.4 '-diaminodiphenylsulfone (Dapsone) was concerned and allowed to...

Open access Research Article 10.9734/CSJI/2018/41427

Characterization of the Molecular Lipophilicity of Mycolactones A/B and C, Infectious Factors of Mycobacterium ulcerans Agent of Buruli Ulcer

Kadjo François Kassi, Jean Missa Ehouman, Mamadou Guy-Richard Koné, Lamoussa Ouattara, Georges Stephane Dembele & Nahossé Ziao · Chemical Science International Journal · 2021

The work was undertaken as part of the Buruli ulcer control program. It is particularly about the determination of the lipophilicity of mycolactones A/B and C, infectious factors of Mycobacterium ulcerans, the agent of Buruli ulcer. The REKKER method and some free software such a...

Open access Research Article 10.9734/CSJI/2021/v30i130211

Predictive Modeling of the Human Hepatoma (Huh-7D12) Cancer Line of a Series of bis- (5-arylidene-rhodanine-3-yl) Diamine

Koffi Alexis Respect Kouassi, Anoubilé Benié, Mamadou Guy-Richard Koné, Wacothon Karime Coulibaly, Kouadio Valery Bohoussou & Adenidji Ganiyou · Asian Journal of Chemical Sciences · 2019

This work deals with the prediction of the antiproliferative activity of eighteen (18) substances derived from bis-5-arylidene rhodanine against human hepatoma tumor line (Huh-7D12). By applying the functional density theory (DFT) method to the B3LYP / 6-31G (d, p) level, theoret...

Open access Research Article 10.9734/ajocs/2019/v6i218993

Predictive Modeling of Breast Anticancer Activity of a Series of Coumarin Derivatives using Quantum Descriptors

Lamoussa Ouattara, Kafoumba Bamba, Mamadou Guy-Richard Koné, Jean Stéphane N’dri, Kouakou Nobel N’Guessan, Ouattara Pierrre Massapihanhoro & Diarrassouba Fatogoman · Chemical Science International Journal · 2019

We focused on a series of coumarin derivatives in this work. The method of Density Functional Theory (DFT) of quantum chemistry has been used at B3LYP / 6-31G (d, p) level in order to identify molecular descriptors which are useful for this study. The analysis of the statistical...

Open access Research Article 10.9734/CSJI/2019/v26i430098

Prediction of the Inhibitory Concentration of Hydroxamic Acids by DFT-QSAR Models on Histone Deacetylase 1

Doh Soro, Lynda Ekou, Mamadou Guy-Richard Koné, Tchirioua Ekou, Sopi Thomas Affi, Lamoussa Ouattara & Nahossé Ziao · International Research Journal of Pure and Applied Chemistry · 2018

In order to study the relationship between inhibitory concentration and the molecular structures of hydroxamic acids, a Quantitative Structure Activity Relationship (QSAR) study is applied to a set of 31 histone deacetylase inhibitors (HDACi). This study is performed by using the...

Open access Research Article 10.9734/IRJPAC/2018/40895

Elaboration of a Predictive Qsar Model of the Anti-Paludial Activity of a Series of Dihydrothiophenone Molecules at Theory Level B3LYP/ 6-31G (d, p)

Fandia Konate, Fatogoma Diarrrassouba, Georges Stephane Dembele, Mamadou Guy-Richard Koné, Bibata Konate & Nahossé Ziao · Chemical Science International Journal · 2021

The purpose of this study is to develop a QSAR model predictive of the antimalarial activity of a series of Dihydrothiophenone molecules using quantum chemical methods. The molecules were optimized from the B3LYP/6-31G (d, p) level of theory. The extracted descriptors are the vib...

Open access Research Article 10.9734/CSJI/2021/v30i830244

QSAR, Pharmacophore and Molecular Docking Studies for the Design of Novel Arylamide-derived Inhibitors of Mycobacterium tuberculosis

Adama Niaré, Abadê Ange-Boris N’guessan, Akassa Marius Bernard Djako, Georges Stephane Dembele, Mamadou Guy-Richard Koné & Yaya Yéo · Chemical Science International Journal · 2024

Tuberculosis is an infectious disease caused by the bacterium Mycobacterium tuberculosis. It remains a significant public health challenge worldwide. In 2022, approximately 10.6 million people were diagnosed with tuberculosis, and 1.3 million individuals lost their lives to the d...

Open access Research Article 10.9734/CSJI/2024/v33i6939