Characterization of the Molecular Lipophilicity of Mycolactones A/B and C, Infectious Factors of Mycobacterium ulcerans Agent of Buruli Ulcer
Kadjo François Kassi, Jean Missa Ehouman, Mamadou Guy-Richard Koné, Lamoussa Ouattara, Georges Stephane Dembele, Nahossé Ziao
Chemical Science International Journal · pp. 18–27 · Published 27 Mar 2021
10.9734/CSJI/2021/v30i130211Abstract
The work was undertaken as part of the Buruli ulcer control program. It is particularly about the determination of the lipophilicity of mycolactones A/B and C, infectious factors of Mycobacterium ulcerans, the agent of Buruli ulcer. The REKKER method and some free software such as MOLINSPIRATION, ACD/ChemSketch and EPIWED were used for the determination of the lipophilicity of mycolactones A/B and C. Very high logP values were found and respectively ranged from 12.11 to 11.41 for mycolactone A/B and 11.69 to 11.58 for mycolactone C. These values obtained from this coefficient, show that mycolactones A/B and C are naturally lipophilic and that actually reflects their effective presence in the subcutaneous fat of the infected area. These results are very encouraging and promising. They are key factors for a better understanding of the biological activities of the two mycolactones and pave the way for the proposal of a mechanism to annihilate their destructive effects.
Cited by 0
No indexed citations yet.
Related research
- Heavy Metals Pollution of Water and Sediment in Mada River, Nigeria — shares topic coverage
- Computer-Aided Design of Anticancer 1,4-Naphthoquinone Derivatives — shares topic coverage
- Octanol-water Partition Coefficients Determination and QSPR Study of Some 3-hydroxy Pyridine-4-one Derivatives — shares topic coverage
- Phenolphthalein Indicator in Titrimetric Estimation of Benzoic Acid Solubility and Distribution in Water and Benzene-Buffer Solutions — shares topic coverage
- Buruli Ulcer (Acha-ere): Pathogenesis and Manifestation — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
0
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.