Cytotoxic agents were the choice of cancer establishments to combat cancer when President Nixon declared War on Cancer in 1971. After the failure to win the war on cancer during the 5 years of intensive presidential support, it was concluded that cytotoxic agents were unable to w...
Introduction: Peutz-Jeghers syndrome (PJS) is an autosomal dominant inherited disorder with incomplete penetrance. It is characterised by gastrointestinal (GI) hamartomatous polyps and mucocutaneous pigmentation, including the lips and gums. The GI hamartomatous polyps in PJS are...
Primary Ewing Sarcoma of vagina is an extremely rare presentation. The atypical site of occurrence and the lack of ample data predispose it to become a substantial challenge in early diagnosis and management. We report a case of isolated Ewing Sarcoma of vagina in a 31 year old f...
Background: Cervical cancer is the commonest malignancy of the female genital tract in developing countries. A preventable disease with a precursor; cervical intraepithelial neoplasia (CIN), is detected by screening methods and it is treated by the use of ablative or excisional m...
Molecular markers may have an effect in the treatment of advanced breast cancers. Our aim is to review and analyze the studies on this subject and to reveal the effect of molecular markers in the treatment of breast cancer. In this review, current studies using molecular markers...
Primary central nervous system lymphoma (PCNSL) is a rare form of extranodal non-hodgkin lymphoma that is confined to the central nervous system. The treatment includes induction chemotherapy followed by whole brain radiation. However, the prognosis is dismal and residual or refr...
According to the World Health organization worldwide Covid -19 related infection is 500 million with 6 million deaths. However, Covid-19 cases and deaths has continued to decline since the end of March 2022, a 24% and 12% decline respectively [1]. The most common symptoms of COVI...
Background: Most prostate cancer diagnosis comes from the histopathological evaluation of specimens obtained from prostate biopsies. It is the standard investigative modality for the diagnosis of prostate cancer. There are clinical, laboratory and imaging indications for prostate...
Currently all approved PD-1/PD-L1 inhibitors are monoclonal antibodies. Along with that, compounds from other chemical classes are being investigated as well. Among those are small molecules which demonstrate commensurable therapeutic effect in preclinical and early clinical deve...
Background : Vulva cancer is a rare but important genital tract malignancy. Aims: This pioneer study was to determine the prevalence, sociodemographics, clinical présentation, histological pattern and treatment outcome at the University of Port Harcourt Teaching Hospital (UPTH)....