Impact of Sildenafil on Smooth Muscle and Blood Vessels by Using Light and Electron Microscopy

Ehab Abou-eladab; Heba Abdal-razzak Abdel-fattah Mahmoud; Hanaa abdel Kader Ibraheem; Ashraf Mahmoud Kamel; Sameh Fawzy Elsonbaty; Faten Shehata

doi:10.9734/BJMMR/2016/25678

Research Article Open access CC BY 4.0

Impact of Sildenafil on Smooth Muscle and Blood Vessels by Using Light and Electron Microscopy

Ehab Abou-eladab, Heba Abdal-razzak Abdel-fattah Mahmoud, Hanaa abdel Kader Ibraheem, Ashraf Mahmoud Kamel, Sameh Fawzy Elsonbaty, Faten Shehata

Journal of Advances in Medicine and Medical Research · pp. 1–9 · Published 28 Jun 2016

10.9734/BJMMR/2016/25678

Abstract

The present study aimed to examine the histological changes in the smooth muscles of corpus cavernosum and veins of rats as an eventual outcome of the ceaseless use of Sildenafil citrate. The comparison of the histological aftereffects of the veins among the control and experimental groups revealed extended thickness of tunica intima and media, as exhibited by a picture analyzer. The findings indicated that the steady usage of Sildenafil reduced smooth muscles and enabled the growth of collagen fibers in corpus cavernosum of penis and mass of veins.

Sildenafil citrate continuous use corpus cavernosum blood vessels.

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Ehab Abou-eladab, Heba Abdal-razzak Abdel-fattah Mahmoud, Hanaa abdel Kader Ibraheem, Ashraf Mahmoud Kamel, Sameh Fawzy Elsonbaty, Faten Shehata (2016). Impact of Sildenafil on Smooth Muscle and Blood Vessels by Using Light and Electron Microscopy. Journal of Advances in Medicine and Medical Research , 1–9. https://doi.org/10.9734/BJMMR/2016/25678

Affiliations

Ehab Abou-eladab — Faculty of Specific Education, Damietta University, New Damietta City, Egypt and Basic Science Department, Alfarabi College for Dentistry and Nursing, Jeddah, Saudi Arabia.
Heba Abdal-razzak Abdel-fattah Mahmoud — Basic Science Department, Alfarabi College for Dentistry and Nursing, Jeddah, Saudi Arabia and Histology Department, Faculty of Medicine, October 6 University, Cairo, Egypt.
Hanaa abdel Kader Ibraheem — Histology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Ashraf Mahmoud Kamel — Histology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Sameh Fawzy Elsonbaty — Histology Department, Faculty of Medicine, October 6 University, Cairo, Egypt.
Faten Shehata — Basic Science Department, Alfarabi College for Dentistry and Nursing, Jeddah, Saudi Arabia.

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