Histological and Biochemical Changes in  Sucrose-Induced Metabolic Syndrome on Kidney of Wistar Rats

M. O. Mohammed; M. Isah; O. O. Okechi; A. T. Muhammad; R. I. Tsamiya; U. Abubakar; I. Mohammed; O. G. Avwioro; A. Umar; S. M. Sani; B. A. Bello; A. A. Ngaski; J. M. Bunza; H. Kabir; A. Abdulaziz; I. Jelani; A. S. Ajayi; F. A. Dogondaji; A. Y. Ma’aruf; A. M. Zakari; K. Bello; D. Sahabi; E. E. Nnadozie

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Histological and Biochemical Changes in Sucrose-Induced Metabolic Syndrome on Kidney of Wistar Rats

M. O. Mohammed, M. Isah, O. O. Okechi, A. T. Muhammad, R. I. Tsamiya, U. Abubakar, I. Mohammed, O. G. Avwioro, A. Umar, S. M. Sani, B. A. Bello, A. A. Ngaski, J. M. Bunza, H. Kabir, A. Abdulaziz, I. Jelani, A. S. Ajayi, F. A. Dogondaji, A. Y. Ma’aruf, A. M. Zakari, K. Bello, D. Sahabi, E. E. Nnadozie

Asian Journal of Research and Reports in Urology · pp. 91–97 · Published 31 Aug 2020

Abstract

Introduction: Metabolic syndrome is a cluster of metabolic abnormalities which confers upon an individual substantial increase risk factors of cardiovascular disease including hypertension, central obesity, dyslipidemia and hyperglycemia. Aim: The aim of the study was to determine the histogical and biochemical parameters changes of kidney of sucrose induced metabolic syndrome in wistar rats. Methodology: A total number of 24 wistar rats were randomly divided into 3 groups. Group A was given plain distilled water which serve as control. Group B was given 10% sucrose distilled water and group C was given 20% sucrose distilled water.The rat was sacrifice by inhalation of chloroform vapour in an enclosed transparent jar. The blood specimens were collected, poured into plain container and analysed for biochemical parameters (Sodium, Potassium, Chloride, Urea, and Creatinine, triglycerides, High density lipoprotein, Body mass index, Uric acid and Glucose).The Kidney was carefully harvested, washed with normal saline, then fixed in 10% formol saline, processed. Sectioned and stained with Ha and E stain. Results: Results obtained revealed that sodium, potassium and chloride of group C (20% sucrose distilled water), the kidney parameters were significantly low when compared with control group. Serum Urea and Creatinine in group B (10%) and group C (20%) shows no statistical difference when compared with control group. The Triglycerides, High density lipoprotein and uric acid shows no statistical significant changes in both groups (10% and 20% sucrose distilled water) when compared with control group but glucose was significantly higher when compared with control group. The histological finding showed no changes on the histology of the kidney in group B (10% sucrose distilled water) but in group C (20% sucrose distilled water) there was scanty deposition of fats cells on the glomeruli. Conclusion: The study shows that sodium, potassium and chloride were very low when compared with control but glucose was significantly higher when compared with control group. The histology of the kidney showed scanty deposition of fats cell in 20% sucrose distilled water.

Sucrose metabolic syndrome hyperglycemia kidneys

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M. O. Mohammed, M. Isah, O. O. Okechi, A. T. Muhammad, R. I. Tsamiya, U. Abubakar, I. Mohammed, O. G. Avwioro, A. Umar, S. M. Sani, B. A. Bello, A. A. Ngaski, J. M. Bunza, H. Kabir, A. Abdulaziz, I. Jelani, A. S. Ajayi, F. A. Dogondaji, A. Y. Ma’aruf, A. M. Zakari, K. Bello, D. Sahabi, E. E. Nnadozie (2020). Histological and Biochemical Changes in Sucrose-Induced Metabolic Syndrome on Kidney of Wistar Rats. Asian Journal of Research and Reports in Urology , 91–97.

Affiliations

M. O. Mohammed — Department of Histopathology, School of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto, Nigeria.
M. Isah — Department of Histopathology, School of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto, Nigeria.
O. O. Okechi — Department of Histopathology, School of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto, Nigeria.
A. T. Muhammad — Department of Histopathology, School of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto, Nigeria.
R. I. Tsamiya — Department of Histopathology, School of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto, Nigeria.
U. Abubakar — Department of Histopathology, School of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto, Nigeria.
I. Mohammed — Department of Histopathology, School of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto, Nigeria.
O. G. Avwioro — Department of Histopathology, School of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto, Nigeria.
A. Umar — Department of Histopathology, School of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto, Nigeria.
S. M. Sani — Department of Histopathology, School of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto, Nigeria.
B. A. Bello — Department of Chemical Pathology, School of Medical Laboratory Science, Usmanu Dandofiyo University, Sokoto, Nigeria.
A. A. Ngaski — Department of Chemical Pathology, School of Medical Laboratory Science, Usmanu Dandofiyo University, Sokoto, Nigeria.
J. M. Bunza — Department of Chemical Pathology, School of Medical Laboratory Science, Usmanu Dandofiyo University, Sokoto, Nigeria.
H. Kabir — Department of Histopathology, School of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto, Nigeria.
A. Abdulaziz — Department of Histopathology, Service Laboratory, Usmanu Danfodiyo University, Teaching Hospital, Sokoto, Nigeria.
I. Jelani — Department of Medical Laboratory Science, College of Health Science, Bayero University, Kano, Nigeria.
A. S. Ajayi — Department of Histopathology, Service Laboratory, Usmanu Danfodiyo University, Teaching Hospital, Sokoto, Nigeria.
F. A. Dogondaji — Department of Histopathology, School of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto, Nigeria.
A. Y. Ma’aruf — Department of Histopathology, School of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto, Nigeria.
A. M. Zakari — Department of Medical Laboratory Science, College of Health Science, Bayero University, Kano, Nigeria.
K. Bello — Department of Chemical Pathology, School of Medical Laboratory Science, Usmanu Dandofiyo University, Sokoto, Nigeria.
D. Sahabi — Department of Chemical Pathology, School of Medical Laboratory Science, Usmanu Dandofiyo University, Sokoto, Nigeria.
E. E. Nnadozie — Department of Chemical Pathology, School of Medical Laboratory Science, Usmanu Dandofiyo University, Sokoto, Nigeria.

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