Evaluation of Anti-hyperlipidemic and Hepato-renal Protective Role of Ethanolic Extract from Mimosa pudica Leaves on High Fat Induced Hyperlipidemic Rat Model

Abstract

Traditional herbal medicine is an ancient field of study that derives its inspiration from natural sources. For thousands of years, it has helped humans fight diseases and protect their health, energy, and ability to reproduce. This study examined the effects of a Mimosa pudica extract on the lipid profiles of rats with hyperlipidemia caused by a high-fat diet. Group 6, which was given a high fat dose of 900 mg/kg, had statistically significant outcomes (p< 0.05) in terms of Serum Glutamic Pyruvic Transaminase (SGPT) levels in relation to the liver function test. The results of the renal function test showed that group 6, which received doses of 900 mg/kg, had a statistically significant elevation in urea levels (p< 0.05). The analysis of creatinine levels in groups 4, 5, and 6 revealed statistically significant results (p< 0.05) for doses of 300, 600, and 900 mg/kg, respectively. Groups 5 and 6 had statistically significant results (p<0.05) for HDL and LDL. Groups 5 and 6 had statistically significant outcomes when administered dosages of 600 and 900 mg/kg, respectively. A statistically significant difference (p< 0.05) was seen in the triglyceride levels between groups 5 and 6. The total cholesterol levels in Group 6, which received a dose of 900 mg/kg, showed statistically significant results (p < 0.05). The main goal of this study is to find out what happens to the lipid profile of hyperlipidemic albino rats when they are given an ethanolic M. pudica extract. The current study in rat models showed that M. pudica had a hyperlipidemic impact, significantly increasing cholesterol levels. The bioactive constituents of the plant, such as tannins, flavonoids, and phenolics, are responsible for its cardioprotective properties. To gain a better understanding of the mechanisms of action of certain bioactive compounds, further analysis of M. pudica's ethanolic extract is required.