Synthesis, Characterization and Biological Evaluation of Thiazolidinedione Substituted Derivatives

Abstract

In modern science of medicinal chemistry, the heterocyclic compounds are playing vital roles in biological activities. Thiazolidine-2,4- Dione are the heterocyclic compounds which were widely used for designing novel drugs which can treat – inflammations, diabetes, seizures and cancer. Thus we tried to synthesize some of the thiazolidine-2,4-dione derivatives. We synthesized thiazolidinedione derivatives from fluorobenzaldehyde, nitrobenzaldehyde& dimethyl aminobenzaldehyde using conventional method and green synthesis method (microwave assisted). These derivatives are characterized using Infrared spectral method and ¹H NMR method and yielded consistent spectral data. Along with the spectral characterization the physicals characterizations such as melting point, TLC, were performed. When comparing the methods of synthesis microwave assisted method shown a significant advantage than the conventional method by producing high amount of yield with required purity of the substance. The derivatives were evaluated for anti-inflammatory activity using In vivo Carrageenan-induced paw edema model. The ‘P’ significance value of all the derivatives were calculated using One-way ANOVA method. Among all the derivatives 5[4-(Nitro) benzylidene]-2,4-thiazolidinedione exhibits notable anti-inflammatory activity.