Synthesis of Novel Derivatives on the Basis of  4-Hydrazinyl-6-methyl-2-(alkylthio)pyrimidines and Their Preliminary Biological Evaluation

Vergush A. Pivazyan; Emma A. Ghazaryan; Roza S. Shainova; Rafael A. Tavalyan; Armen G. Ayvazyan; Aleksandr P. Yengoyan

doi:10.9734/ACSJ/2016/28201

Research Article Open access CC BY 4.0

Synthesis of Novel Derivatives on the Basis of 4-Hydrazinyl-6-methyl-2-(alkylthio)pyrimidines and Their Preliminary Biological Evaluation

Vergush A. Pivazyan, Emma A. Ghazaryan, Roza S. Shainova, Rafael A. Tavalyan, Armen G. Ayvazyan, Aleksandr P. Yengoyan

Chemical Science International Journal · pp. 1–10 · Published 27 Aug 2016

10.9734/ACSJ/2016/28201

Abstract

By functionalization of 4-hydrazinyl-6-methyl-2-(alkylthio)pyrimidines the corresponding acetohydrazides, N-phenylhydrazine-1-carboxamides(thioamides) were obtained. The heterocyclization of the same hydrazides lead to nonfused pyrazolyl-pyrimidines and pyridazinyl-pyrimidines and a series of 3-S-substituted derivatives of fused 1,2,4-triazolo[4,3-c]pyrimidine. The preliminary in vitro tests have shown that among the synthesized compounds there are substances exhibiting growth promoting properties.

4-hydrazinyl-6-methyl-2-(alkylthio)pyrimidines N-phenylhydrazine-1-carboxamides and thioamides heterocyclization pyrazolyl-pyrimidines pyridazinyl-pyrimidines 1,2,4-triazolo[4,3-c]pyrimidines growth stimulant activity

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Vergush A. Pivazyan, Emma A. Ghazaryan, Roza S. Shainova, Rafael A. Tavalyan, Armen G. Ayvazyan, Aleksandr P. Yengoyan (2016). Synthesis of Novel Derivatives on the Basis of 4-Hydrazinyl-6-methyl-2-(alkylthio)pyrimidines and Their Preliminary Biological Evaluation. Chemical Science International Journal , 1–10. https://doi.org/10.9734/ACSJ/2016/28201

Affiliations

Vergush A. Pivazyan — Laboratory of Plant Protection and Pesticides Synthesis, National Agrarian University of Armenia, 34 Teryan str., Yerevan, 0009, Armenia
Emma A. Ghazaryan — Laboratory of Plant Protection and Pesticides Synthesis, National Agrarian University of Armenia, 34 Teryan str., Yerevan, 0009, Armenia
Roza S. Shainova — Laboratory of Plant Protection and Pesticides Synthesis, National Agrarian University of Armenia, 34 Teryan str., Yerevan, 0009, Armenia and Department of Chemistry, Russian-Armenian (Slavonic) State University, 123 H. Emin str., Yerevan, 0051, Armenia
Rafael A. Tavalyan — STC OPC Molecule Structure Research Center NAS RA, Yerevan, Armenia, 26 Azatutyan av., Yerevan, 0014, Armenia
Armen G. Ayvazyan — STC OPC Molecule Structure Research Center NAS RA, Yerevan, Armenia, 26 Azatutyan av., Yerevan, 0014, Armenia
Aleksandr P. Yengoyan — Laboratory of Plant Protection and Pesticides Synthesis, National Agrarian University of Armenia, 34 Teryan str., Yerevan, 0009, Armenia and Department of Chemistry, Russian-Armenian (Slavonic) State University, 123 H. Emin str., Yerevan, 0051, Armenia

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