In vitro Evaluation of Anticancer Activity of the Methanolic and  Aqueous Extracts of the Petals of  C. tinctorius L. (Safflower Florets)

Ayesha Sultana; S. Y. Anwar; Md. Manazzir Hussain; B. Akhil Raj

Research Article Open access CC BY 4.0

In vitro Evaluation of Anticancer Activity of the Methanolic and Aqueous Extracts of the Petals of C. tinctorius L. (Safflower Florets)

Ayesha Sultana, S. Y. Anwar, Md. Manazzir Hussain, B. Akhil Raj

Asian Journal of Biotechnology and Genetic Engineering · pp. 82–86 · Published 26 Jun 2023

Abstract

The anticancer activity of the methanolic and aqueous extracts of the petals of safflower florets were analyzed using breast cancer cell lines namely MCF-7. The, MCF-7 cells were incubated with increasing concentrations of the methanolic and aqueous extract of the petals ranging from 5-150ug/ml for different time periods (6, 12, 18, 24, 36, 48, 72) and the cell viability was analyzed using MTT assay, aqueous extract of safflower florets Manjira and SSf-658 was found to be potent cytotoxic (IC50 value 34.17,36.96µg/ml) as similar to standard drug cisplatin. In addition to methanol extract pbns-12 was found to be potent cytotoxic with IC50 value 47.401±3.991 respectively.

C. tinctorius florets secondary metabolites anticancer activity cisplatin drug

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Ayesha Sultana, S. Y. Anwar, Md. Manazzir Hussain, B. Akhil Raj (2023). In vitro Evaluation of Anticancer Activity of the Methanolic and Aqueous Extracts of the Petals of C. tinctorius L. (Safflower Florets). Asian Journal of Biotechnology and Genetic Engineering , 82–86.

Affiliations

Ayesha Sultana — Department of Genetics and Biotechnology, Osmania University, Hyderabad, Government Medical College, Nalgonda, Telangana, India.
S. Y. Anwar — Department of Genetics and Biotechnology, Osmania University, Hyderabad, Government Medical College, Nalgonda, Telangana, India.
Md. Manazzir Hussain — Department of Genetics and Biotechnology, Osmania University, Hyderabad, Government Medical College, Nalgonda, Telangana, India.
B. Akhil Raj — Department of Genetics and Biotechnology, Osmania University, Hyderabad, Government Medical College, Nalgonda, Telangana, India.

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