Effects of Silymarin on Oxidative Stress Markers in Rats Treated with Magnesium Oxide Nanoparticles
Masoud Negahdary, Mahnaz Bezhgi, Marziyeh Ajdary
Annual Research & Review in Biology · pp. 254–261 · Published 6 Oct 2014
10.9734/ARRB/2015/10949Abstract
This study investigated the protective and anti-oxidative effects of silymarin on rats treated with MgO NPs. Number of 32 male wistar rats were used in this experiment, assigned to four groups; one, the control group and the three others were treatment groups. The treated groups inclusive of a group receiving 400 ppm Mg NPs, a group received 200 mg/kg silymarin, and a group received silymarin and that dose of Mg NPs. All groups received the treatment peritoneally as long as four weeks uninterruptedly. Post-treatment tissue level of malondialdehyde as well as the activities of catalase, glutathione peroxidase and superoxide dismutase were measured in the liver. The data were analyzed by implementation of one-way ANOVA and Bonferroni tests. In animals treated with MgO NPs, MDA level significantly increased (P=0.000), while a significant decrease was observed in GPX (P=0.000), SOD (P=0.001), and CAT (P=0.008) activities. However, silymarin prevented the effect of them in the group receiving silymarin and MgO NPs significantly and caused an increase in GPX, SOD and CAT activities as well as a decrease in MDA level (P<0.05). As, nanoparticles have harmful effects on the body raised from the generation of reactive oxygen species, this study showed that silymarin, with its antioxidant properties, may decrease free radicals produced by MgO NPs.
Cited by 11
Mehdi Shahsavan · Worlds Poultry Science Journal · 2024
Seda Şimşek, Merve Solmaz, I. H. Nur · Revista Científica de la Facultad de Ciencias Veterinarias · 2024
M. A. E. Hassan, M. Ragab, S. Shazly · Journal of animal physiology and animal nutrition · 2024
Abd El-Ghany WA. Abd El-Ghany WA. · Online Journal of Animal and Feed Research · 2022
R. Khazaei, A. Seidavi, M. Bouyeh · Veterinary Medicine and Science · 2021
Forough Masoumi, M. Shariati, M. Mokhtari · 2020
Zeinab Morshedtalab, G. Rahimi, Asieh Emami-Nejad · Current Topics in Medicinal Chemistry · 2020
Hanaa S. E. Mousa, K. Abdelfadeel, Mohammad Hassan · 2019
H. Abdel-Aziz, Zeinab M. Alazouny, K. Abdelfadeel · 2019
Bahram Jamali Gharakhanlou, Bita Rahmani, Akram Amaghani · 2023
Related research
- Morphological and Biochemical Effects of Aqueous Extract of Moringa oleifera Leaf on Cobalt Chloride-Induced Cerebral Damage in Adult Wistar Rats — shares topic coverage
- Evaluation of Antioxidants, and Haematological Indices in Glaucoma Patients: A Case Study of Bayelsa State, Nigeria — shares topic coverage
- Oxidative Stress Biomarkers (Malondialdehyde, Superoxide Dismutase, and Catalase) as Predictors of Cardiovascular Disease Risk: A Review — shares topic coverage
- Determination of SOD, POD, PPO and CAT Enzyme Activities in Rumex obtusifolius L. — shares topic coverage
- Combinational Effect of Cajanus cajan, Silybum marianum and Andrographis paniculata on In vivo Antioxidant and Hepatoprotective Activities of Carbon Tetrachloride Intoxicated Albino Rats — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
11
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.