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Research Article Open access CC BY 3.0

Synthesis and Antibacterial Activity of N,N-Diethylamide Bearing Benzenesulfonamide Derivatives

Olayinka O. Ajani, Oluwole B. Familoni, Johnbull O. Echeme, Feipeng Wu, Zheng Sujiang

Chemical Science International Journal · pp. 34–49 · Published 25 Jan 2013

10.9734/ACSJ/2013/2397

Abstract

Sulfonamides are known to represent a class of medicinally important compounds which are extensively used as antibacterial agents. Hence, a series of new N,N-diethyl amide bearing sulfonamides (2a-k) were synthesized via amidation of easily prepared benzenesulfonamide precursors (1a-k). The chemical structures of all synthesized compounds were substantiated using spectroscopic means such as IR, Mass spectra and 1H-NMR as well as analytical data. The antimicrobial activity of these compounds along with streptomycin, was investigated on Escherichia coli and Staphylococcus aureus. The results showed that this skeletal framework exhibited marked potency as antibacterial agents. The most active antibacterial agent against both targeted organisms was N,N-diethyl-1-(phenylsulfonyl) piperidine-2-carboxamide (2b).  

2-(Phenylsulfonamido) acetic acid inhibition zone N,N-diethylamide antibacterial study streptomycin

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