Synthesis and Antibacterial Activity of N,N-Diethylamide Bearing Benzenesulfonamide Derivatives
Olayinka O. Ajani, Oluwole B. Familoni, Johnbull O. Echeme, Feipeng Wu, Zheng Sujiang
Chemical Science International Journal · pp. 34–49 · Published 25 Jan 2013
10.9734/ACSJ/2013/2397Abstract
Sulfonamides are known to represent a class of medicinally important compounds which are extensively used as antibacterial agents. Hence, a series of new N,N-diethyl amide bearing sulfonamides (2a-k) were synthesized via amidation of easily prepared benzenesulfonamide precursors (1a-k). The chemical structures of all synthesized compounds were substantiated using spectroscopic means such as IR, Mass spectra and 1H-NMR as well as analytical data. The antimicrobial activity of these compounds along with streptomycin, was investigated on Escherichia coli and Staphylococcus aureus. The results showed that this skeletal framework exhibited marked potency as antibacterial agents. The most active antibacterial agent against both targeted organisms was N,N-diethyl-1-(phenylsulfonyl) piperidine-2-carboxamide (2b).
References (29)
- 1 The Merck index
- 2 The pathogenic basis of malaria [DOI]
- 3 The Nobel Prize in Physiology or Medicine [DOI]
- 4 Synthesis and in vitro antitumor evaluation of some indeno[1,2-c]pyrazol(in)es substituted with sulfonamide, sulfonylurea(-thiourea) pharmacophores, and some derived thiazole ring systems [DOI]
- 5 Microwave assisted synthesis and antimicrobial activity of 2-quinoxalinone-3-hydrazone derivatives [DOI]
- 6 Synthesis of new coumarin 3-(N-aryl) sulfonamides and their anticancer activity [DOI]
- 7 COX-2 Selective Inhibitors, Carbonic Anhydrase Inhibition and Anticancer Properties of Sulfonamides Belonging to This Class of Pharmacological Agents [DOI]
- 8 Direct Conversion of Thiols to Sulfonyl Chlorides and Sulfonamides [DOI]
- 9 Synthesis, characterization and antimicrobial activity of new aliphatic sulfonamide [DOI]
- 10 Synthesis and Antiviral Activity of 5‑(4‑Chlorophenyl)-1,3,4-Thiadiazole Sulfonamides [DOI]
- 11 N-Acylbenzotriazoles: Neutral Acylating Reagents for the Preparation of Primary, Secondary, and Tertiary Amides [DOI]
- 12 The Antibacterial Activity of a New Chloroxylenol Preparation Containing Ethylenediamine Tetraacetic Acid [DOI]
- 13 Chemoselective Acylation of Amines in Aqueous Media [DOI]
- 14 Antimicrobial activity of some sulfonamide derivatives on clinical isolates of Staphylococus aureus [DOI]
- 15 Design and synthesis of 3-alkyl-2-aryl-1,3-thiazinan-4-one derivatives as selective cyclooxygenase (COX-2) inhibitors [DOI]
- 16 Antimicrobial potentials of Diospyros mespiliformis (Ebenaceae).
- 17 Evaluation of antibacterial activity of Pisidium guajava and Gongronema Latifolium [DOI]
- 18 In-vitroantibacterial, antifungal and cytotoxic properties of metal-based furanyl derived sulfonamides [DOI]
- 19 Synthesis and SAR/3D-QSAR studies on the COX-2 inhibitory activity of 1,5-diarylpyrazoles to validate the modified pharmacophore [DOI]
- 20 Inhibition of clinically significant bacterial organisms in vitro by 2-acetylpyridine thiosemicarbazones [DOI]
- 21 Biological Activities Of Sulfonamides
- 22 Synthesis and antimicrobial activity of some new macrocyclic bis-sulfonamide and disulfides [DOI]
- 23 Synthesis and evaluation of antimicrobial activity of phenyl and furan-2-yl[1,2,4] triazolo[4,3-a]quinoxalin-4(5H)-one and their hydrazone precursors.
- 24 Tritylamine as an ammonia synthetic equivalent: preparation of primary amides [DOI]
- 25 Room Temperature Synthesis and Antibacterial Activity of New Sulfonamides Containing N,N-Diethyl-Substituted Amido Moieties [DOI]
- 26 Pharmacophoric 2-hydroxyalkyl benzenesulfonamide: A single-step synthesis from benzenesulfonamide via hemiaminal [DOI]
- 27 Characterization of Anti-HIV Activity Mediated by HIV-1 Integrase C-terminal Domain Polypeptides Expressed in Susceptible Cells [DOI]
- 28 ChemInform Abstract: Intramolecular Anionic Friedel—Crafts Equivalents. An Expeditious Synthesis of 4H‐1,2‐Benzothiazin‐4‐one 1,1‐Dioxides from N‐Arylsulfonylated Amino Acids. [DOI]
- 29 Synthesis of 2‐Arylindole‐4‐Carboxylic Amides: [2‐(4‐Fluorophenyl)‐1 H ‐Indol‐4‐ YL ]‐1‐Pyrrolidinylmethanone [DOI]
Cited by 5
Junchen Zhu, Lunan Zhu, Yaling Wu · Journal of Separation Science · 2020
Salwa Mansur Ali, Ruqaiyyah Siddiqui, Seng-Kai Ong · Applied Microbiology and Biotechnology · 2016
Sana Hitur Awad, Sana Abdul Sahib, Fatimah Ali Hussein · IOP Conference Series: Materials Science and Engineering · 2019
Wafaa S. Abo El-Yazeed, O. R. Hayes, Awad I. Ahmed · Journal of Sol-Gel Science and Technology · 2022
Kyalo Stephen Kanyiva, Kanako Uchida, Takanori Shibata · Bulletin of the Chemical Society of Japan · 2021
Related research
- Differential Antimicrobial Effects of Conventional and Ethnobotanical Extracts from Vitellaria paradoxa Roots, Barks and Leaves — shares topic coverage
- In vitro Bioluminescence Used as a Method for Real-Time Inhibition Zone Testing for Antibiotic-Releasing Composites — shares topic coverage
- Allelopathic Activity of Some Medicinal Plants against Erwinia carotovora — shares topic coverage
- Exploration of Phytochemical and Antibacterial Potentiality of Anagallis arvensis L. Extract against Methicillin-Resistant Staphylococcus aureus (MRSA) — shares topic coverage
- Catalytic, Antioxidant, Antibacterial and Antidiabetic Activities of AgNPs Derived from Seed Kernel Extract of Entada rheedii Spreng. — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
5
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.