Phytochemical Composition, Antibacterial Activities against Multi-Resistant Strains of Pseudomonas aeruginosa and Acinetobacter baumannii of the Bark Extract of Ficus platyphylla Dell. Holl.

Abstract

Ficus platyphylla Ficus platyphylla belongs to the Moraceae family which contains nearly 1400 species divided into around forty genera. It is used to manage several diseases in folklore medicine. This study focused on the phytochemical screening and evaluation of the antibacterial potential against Pseudomona aeruginosa and Acinetobacter baumannii of hydroethanolic extract from Ficus platyphylla (FP) bark. Phytochemical and antibacterial activity were carried out according to the literature procedure. Qualitative analyses of FP revealed the presence polyphenols, flavonoids, coumarins, tannins, alkaloids, sterols and terpenes. Quantitative analysis by spectrophotometry showed a phenolic compound content to be 0.878 ± 0.02 mg EAG/g DM. The flavonoids content was 0.084 ± 0.02 mg EQ/g DM, while flavonic aglycones, anthocyanins and condensed tannins were 0.014 mg EQ/g DM, 0.018 mg EQ/g DM and 0.189 mg EC/g DM, respectively. In vivo antibacterial activity showed that (FP) was ineffective against six (06) multi-resistant strains of Pseudomonas aeruginosa and Acinetobacter baumannii.