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Research Article Open access CC BY 4.0

A Case Report of an Advanced Stage Gastrointestinal Stromal Tumor Successfully Treated by Surgery and Imatinib

Ashraf Saad Meligy, Ashraf ALakkad, Fadi Bassam Almahameed, Aref Chehal

Asian Journal of Medicine and Health · pp. 141–147 · Published 8 Oct 2022

10.9734/ajmah/2022/v20i11753

Abstract

Background: The most prevalent gastrointestinal sarcoma is a gastrointestinal stromal tumor.It is frequently misdiagnosed due to its indolent symptoms, which only manifest at an advanced and potentially incurable stage. Case Report: This case report is that ofa recent case of a GIST of gastric origin. Itdiscusses the case of a 56-year-old, non-smoking male with no comorbiditieswho presented to the emergency department with severe colicky intermittent adnominal pain that had occurred over the past three days, approximately three years ago. On September3, 2019, the patient underwent laparotomy in which a mass and related small bowel segment (the part of the omentum) was removed. Later, the pathology profile revealed a neoplasm of the small bowel-Ileum, Gastrointestinal stromal tumor (GIST) with a high-risk tumor of stage 4 with no recorded nodular involvement and no recorded metastasis pT4 pNxpMx but with clear margins. Moreover, the tumor markers KIT (CD117), CD34, and DOG1 (ANO1) were found to be positive. Ki67 was noted up to 35%. However, S-100 and SMA were found to be negative. On gross examination, the lesion's greatest dimension was 11 cm, and other dimensions were 9x6 cm. The tumor had a spindle-shaped morphology. On the basis of these laboratory findings and pathology profile, the patient's diagnosis was a Gastrointestinal Stromal tumor thatwas managed viasurgery. At that time, the patient was also prescribed Imatinib 400 mg. It has been three years since then, our patient is still alive, and no cancer recurrence has been reported yet. Conclusion: This case report revealed that interventional radiology's early engagement with the surgical procedure was the cornerstone of our patient's effective treatment and should be investigated at different stages of the gastrointestinal tumor.

Gastrointestinal stromal tumor GIST c-Kit small intestine imatinib

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