A Huge Liposarcoma: Case Study

Abstract

A 53-year-old had complaints of vague abdominal pain for the past few months. The patient had a history of diabetes mellitus, hypertension, and iron deficiency. The pain was aching, mild, intermittent, non-radiating, and generalized. An ultrasound of the abdomen, CT scan and MRI were recommended. After initial examination and reports, the patient was diagnosed with a retroperitoneal tumor. The liposarcoma found was dedifferentiated, high grade, and retroperitoneal. The tumor extended to the inked resection margin, and was large, with 24 cm and 14 cm in greatest dimension measurements.  The liposarcoma was lipomatous and solid, with hot spots of mitosis. In terms of treatment, surgery was recommended to remove the enlarged mass. Two heterologous fragments, which were different in morphology, size, and color, were obtained from the retroperitoneal area during surgery. The mass was a huge grade 3 liposarcoma with a mitotic rate of > 20 mitoses per 10 high-power fields (HPF). The examination and diagnosis included some special studies such as immunohistochemistry assay, which was positive for p16, vimentin, and MDM2. A post-operative scan showed that there was no evidence of recurrence or residual retroperitoneal tumour. Chemotherapy was initiated by the Oncology Department.