A Narrative Review on Neuromyelitis Optica
Gabriel Alugba, Alexsandra Urhi, Gibson O. Anugwom, Samuel O. Ilikannu, Omotola Akinade, Oboseh J. Ogedegbe, Tioluwani K. Ojo, Ayodeji D. Johnson, Kingsley C. Nwadi
Journal of Advances in Medicine and Medical Research · pp. 24–44 · Published 2 May 2022
10.9734/jammr/2022/v34i1331377Abstract
Neuromyelitis Optica, also known as Devic's disease, is a central nervous system (CNS) autoimmune inflammatory disease that primarily affects the optic nerve and spinal cord. The mechanism of the disease is given by the generation of IgG antibodies, whose major target is the aquaporin channel 4 (AQP4), causing an inflammatory and demyelinating process in the aforementioned tissues. In this study, we discussed extensively this disease entity by describing the epidemiology, pathogenesis, clinical features, management, and prognosis.
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