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Research Article Open access CC BY 4.0

A Rare Case of Leiomyomatosis Peritonalis Disseminata

Chijioke O. Ezeigwe, Uchenna D. Okudo, Onyeka C. Ekwebene, Emmanuel C. Egwuatu, Daniel C. Anyiam, Jerome C. Okudo, Oyetokunbo Ibidapo-Obe, George U. Eleje, Charlotte B. Oguejiofor, Nkejesus C. Obi, Victor K. Nwodo

International Journal of Medical and Pharmaceutical Case Reports · pp. 1–4 · Published 22 Aug 2023

10.9734/ijmpcr/2023/v16i4341

Abstract

Leiomyomatosis Peritonalis Disseminata (LPD), also known as disseminated peritoneal leiomyomatosis is an extremely rare disease in women and men where there is a rapid increase in peritoneal and subperitoneal nodules mainly of smooth muscle cells. It is a benign condition, however, its diagnosis can mimic or degenerate into peritoneal leiomyosarcoma, making the diagnosis tricky. In addition, clinical manifestations can be very nonspecific. We discuss the case of a 38-year-old  nulliparous patient  who presented to the clinic with a 2-year history of lower abdominal swelling and a 5-month history of severe menorrhagia. Intraoperative findings showed an enlarged uterus with  subserosal fibroids and several  deposits on the serosa and intestines. The patient had Total hysterectomy and bilateral-salpingoophorectomy. Because malignant transformation has been reported to potentially occur almost 10 years from initial diagnosis, patients should be monitored by repeat ultrasound scans.

Leiomyomatosis peritonalis disseminata subserosal fibroids malignant transformation estrogen

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