A Review on Acute Toxicity Studies of Azadirachta indica

Abstract

Azardirachta indica, commonly referred to as neem, is a traditional Indian plant recognized for its therapeutic properties. It has been utilized in the treatment of numerous health issues due to its diverse activities, including anti-diabetic, anti-cancer, anti-bacterial, anti-fungal, and anti-inflammatory effects, among others. Neem oil, which has anti-inflammatory and wound-healing qualities, is its most popular version. In the pharmaceutical and pharmaceutical sectors, it is also utilized as a solvent and as a field fertilizer. The Occupational Safety and Health Administration (OSHA) and the American Conference of Governmental Industrial Hygienists (ACGIH) state that acute oral toxicity of ethanol neem containing 3000 ppm Azardirachtin is registered with the Environmental Protection Agency (EPA) in the United States. These values are based on experimental data. According to a study, neem oil caused acute cutaneous toxicity that caused primary skin irritation in rats and rabbits, with rat 24-hour LD50s of 14 and 24 ml/kg, respectively. The toxicity of aqueous leaf extract in chickens (Gallus domesticus) was found to be dosage dependent. Conclusion: Numerous research' conclusions advise using them cautiously and checking for dose dependency. This page provides a thorough analysis of the findings of several studies on Azardirachta Indica’s acute toxicity.