A Review on Current Status and Future Prospectus of Oral Vaccines
Asian Journal of Medicine and Health · pp. 21–37 · Published 6 Jul 2021
10.9734/ajmah/2021/v19i730342Abstract
The second leading reason of mortality worldwide is communicable diseases. The highly cost effective approach for disease prevention in case of communicable disease is vaccination. It is need of the hour to design and develop novel as well as safe vaccine delivery systems to safeguard against present incurable and emerging diseases. For various factors, the production of orally administered vaccines is superior to conventional injection-based formulations, including increased protection and compliance, and simplified processing and administration. In comparison, the oral route helps humoral and cellular immune responses to be activated at both systemic and mucosal sites to create larger and longer-lasting defence. This review addresses the reasoning for oral vaccines here including important biological and physicochemical implications for the design of oral vaccines for the next decade.
References (79)
- 1 PLGA-based nanoparticles: An overview of biomedical applications [DOI]
- 2 Regional specialization within the intestinal immune system [DOI]
- 3 Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies [DOI]
- 4 Oral drug delivery with polymeric nanoparticles: The gastrointestinal mucus barriers [DOI]
- 5 Mucosal immunity and vaccines [DOI]
- 6 Retinoic Acid Imprints Gut-Homing Specificity on T Cells [DOI]
- 7 Barrier properties of mucus [DOI]
- 8 The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system [DOI]
- 9 Mucosal vaccines: the promise and the challenge [DOI]
- 10 Recent progress in mucosal vaccine development: potential and limitations [DOI]
- 11 Visual Evidence of Acidic Environment Within Degrading Poly(lactic-co-glycolic acid) (PLGA) Microspheres [DOI]
- 12 Approaches for enhancing oral bioavailability of peptides and proteins [DOI]
- 13 Strategies intended to address vaccine hesitancy: Review of published reviews [DOI]
- 14 Engineering synthetic vaccines using cues from natural immunity [DOI]
- 15 The intestinal epithelial stem cell [DOI]
- 16 Preferential Generation of Follicular B Helper T Cells from Foxp3 + T Cells in Gut Peyer's Patches [DOI]
- 17 Nanotechnology in vaccine delivery [DOI]
- 18 Recent advances on the use of biodegradable microparticles and nanoparticles in controlled drug delivery [DOI]
- 19 Needle-free vaccine delivery☆ [DOI]
- 20 Nanoparticles for oral delivery: Targeted nanoparticles with peptidic ligands for oral protein delivery [DOI]
- 21 Chitosan nanoparticles for oral drug and gene delivery [DOI]
- 22 Gut instincts: Explorations in intestinal physiology and drug delivery [DOI]
- 23 Gut instincts: thoughts on intestinal epithelial stem cells [DOI]
- 24 Hydrogels and Scaffolds for Immunomodulation [DOI]
- 25 Single Mucosal, but Not Parenteral, Immunization with Recombinant Adenoviral-Based Vaccine Provides Potent Protection from Pulmonary Tuberculosis [DOI]
- 26 Emerging Trends in Oral Delivery of Peptide and Protein Drugs [DOI]
- 27 Rationalizing the development of live attenuated virus vaccines [DOI]
- 28 PEGylated PLGA-based nanoparticles targeting M cells for oral vaccination [DOI]
- 29 Classification and functions of enteroendocrine cells of the lower gastrointestinal tract [DOI]
- 30 Vaccine adjuvants: Current challenges and future approaches [DOI]
- 31 Occupational exposure to needlestick injuries and hepatitis B vaccination coverage among health care workers in Egypt [DOI]
- 32 Immunology of gut mucosal vaccines [DOI]
- 33 Keynote review: Intestinal Peyer's patch M cells and oral vaccine targeting [DOI]
- 34 Bridging the knowledge gaps in vaccine design [DOI]
- 35 Delivery strategies to enhance oral vaccination against enteric infections [DOI]
- 36 Vaccines against mucosal infections [DOI]
- 37 Rotavirus vaccination: a concise review [DOI]
- 38 Single-injection vaccines: Progress, challenges, and opportunities [DOI]
- 39 Towards tailored vaccine delivery: Needs, challenges and perspectives [DOI]
- 40 New knowledge on pathogenesis of bacterial enteric infections as applied to vaccine development [DOI]
- 41 Epidemiology of Poliomyelitis in the United States One Decade after the Last Reported Case of Indigenous Wild Virus-Associated Disease [DOI]
- 42 The Intangible Value of Vaccination [DOI]
- 43 Comparative Efficacy of Two, Three, or Four Doses of TY21a Live Oral Typhoid Vaccine in Enteric-Coated Capsules: A Field Trial in an Endemic Area [DOI]
- 44 Efficacy of one or two doses of Ty21a Salmonella typhi vaccine in enteric-coated capsules in a controlled field trial [DOI]
- 45 Delivery systems for penetration enhancement of peptide and protein drugs: design considerations [DOI]
- 46 Immunoadjuvant capacity of flagellin and mannosamine-coated poly(anhydride) nanoparticles in oral vaccination [DOI]
- 47 PEG–PLA–PEG block copolymeric nanoparticles for oral immunization against hepatitis B [DOI]
- 48 Administration strategies for proteins and peptides [DOI]
- 49 Control of adenovirus acute respiratory disease in U.S. Army trainees.
- 50 Poly anhydride nanoparticles as adjuvants for mucosal vaccination [DOI]
- 51 Intestinal epithelial cells: regulators of barrier function and immune homeostasis [DOI]
- 52 The adherent gastrointestinal mucus gel layer: thickness and physical state in vivo [DOI]
- 53 Epithelial antimicrobial defence of the skin and intestine [DOI]
- 54 Survey of the prevalence of immunization non-compliance due to needle fears in children and adults [DOI]
- 55 The intestinal epithelial stem cell: the mucosal governor [DOI]
- 56 Physiological Parameters for Oral Delivery and in Vitro Testing [DOI]
- 57 Vaccine impact: Benefits for human health [DOI]
- 58 What Role Does the Route of Immunization Play in the Generation of Protective Immunity against Mucosal Pathogens? [DOI]
- 59 Vaccine technologies: From whole organisms to rationally designed protein assemblies [DOI]
- 60 Large intestine–targeted, nanoparticle-releasing oral vaccine to control genitorectal viral infection [DOI]
- 61 Virulence factors, pathogenesis and vaccine protection in cholera and ETEC diarrhea [DOI]
- 62 Targeting nanoparticles to M cells with non-peptidic ligands for oral vaccination [DOI]
- 63 Vaccine delivery carriers: Insights and future perspectives [DOI]
- 64 Subsets of migrating intestinal dendritic cells [DOI]
- 65 Current management of the gastrointestinal complications of systemic sclerosis [DOI]
- 66 Perspectives on Mucosal Vaccines: Is Mucosal Tolerance a Barrier? [DOI]
- 67 Poly(Anhydride) Nanoparticles Act as Active Th1 Adjuvants through Toll-Like Receptor Exploitation [DOI]
- 68 Oral vaccine delivery [DOI]
- 69 Digestion of Nucleic Acids Starts in the Stomach [DOI]
- 70 Food-associated stimuli enhance barrier properties of gastrointestinal mucus [DOI]
- 71 Is There an Optimal Formulation and Delivery Strategy for Subunit Vaccines? [DOI]
- 72 Induction of mucosal and systemic immune response by single-dose oral immunization with biodegradable microparticles containing DNA encoding HBsAg [DOI]
- 73 Formulation, characterization and evaluation of rotavirus encapsulated PLA and PLGA particles for oral vaccination [DOI]
- 74 Complexation hydrogels as potential carriers in oral vaccine delivery systems [DOI]
- 75 Polyanhydride Nanovaccines Induce Germinal Center B Cell Formation and Sustained Serum Antibody Responses [DOI]
- 76 Viral Vaccination Via the Mucosal Routes [DOI]
- 77 THE COSTS OF INTRODUCING A MALARIA VACCINE THROUGH THE EXPANDED PROGRAM ON IMMUNIZATION IN TANZANIA [DOI]
- 78 Investigation of 3-D ordered materials with a high adsorption capacity for BSA and their potential application as an oral vaccine adjuvant [DOI]
- 79 Re-born in the USA: Another cholera vaccine for travellers [DOI]
Cited by 1
Maykon Jhuly Martins de Paiva, Edielma de Oliveira Lara, Francyslayne de Jesus Oliveira · Journal of Advances in Medicine and Medical Research · 2024
Related research
- Epidemiological Profile of HIV among Elderly in Brazil from 2019 to 2023 — shares topic coverage
- Vaccination Coverage Against Human Papillomavirus (HPV) : A Study on Vaccination in the Municipality of Ananindeua, Brazil — shares topic coverage
- Dynamics of Urban Arboviruses Transmitted by Aedes Aegypti in Brazil: Integrative Literature Review — shares topic coverage
- Effect of Communicable Diseases on the Economy: A Panel Data Analysis — shares topic coverage
- A Review on Human Metapneumovirus and Human Bocavirus Associated with Acute Respiratory Tract Infections — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
1
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.