Alterations in Biochemical Markers of Kidney Function of Thyroid Disorders at Vidharbha Region, India

Abstract

Background: The thyroid gland is a major endocrine gland in the body that is located in the front of the neck. Thyroid disorders cause problems on kidney function in a variety of ways. Hyperthyroidism causes an increase in both RBF and GFR. The expression of cardiac beta-adrenergic receptors may be influenced by thyroid hormones. The increased catecholamine sensitivity of beta adrenergic coupled cardiac responses in hyperthyroid patients may be due to the increased number of receptors. ROS may be one of the main causes of kidney failure in thyroid disorders, although this needs to be confirmed in the lab. Aim: The aim of this research was to look at the effects of thyroid disorders on kidney function and oxidative stress markers, as well as the relationship between them. Materials and Methods: After visiting Shalinitai Meghe hospital in Nagpur for a health check-up, a total of 350 people were chosen for the research. This was the place where the five groups were held. Subclinical Hypothyroidism: 70 subjects, Overt Hypothyroidism: 70 subjects, Subclinical Hyperthyroidism: 70 subjects, Overt Hyperthyroidism: 70 subjects. There are 70 patients in each household. Specific biochemical methods were used to quantify biochemical parameters such as T3, T4, TSH, Urea, Creatinine, and Cys C. Assay of Superoxide dismutase by Marklund and Marklund method ResultS: In our work, we discovered a significant positive correlation between serum creatinine and TSH in hypothyroidism and hyperthyroidism, and a significant negative correlation between serum Cystatin C and TSH in hypothyroidism and hyperthyroidism. TSH was linked to oxidative stress markers as well. When the oxidative stress markers MDA and SOD were statistically analysed, they were found to be highly associated with markers of kidney function. Conclusion:When the incidence of chronic kidney disease rises, all instances of hypothyroidism and hyperthyroidism should be regularly tested for worsening kidney functions, and since the study indicates that oxidative stress plays a role in nephropathy, current thyroid disorders treatment methods should include oxidative stress, which will aid clinicians in better managing kidney dysfunction.