Ameliorative Activities of Morus and Jamun against Cr Induced Andro-Hepatic Anomalies

Abstract

Chromium (Cr) is a vital micronutrient for sugar metabolism while its unauthorized use may agonize health fatalities. This study was conducted about the novelty about exposure of hexavalent chromium (Cr+6) histopatholgical potentials along with Mulberry Fruit Extract and Jamun Fruit Extract to define the ameliorative aptitude. The histological finding in Cr exposure specify; cessation of testicular seminiferous tubules (ST), annihilation of smooth muscles in basement membrane, Leydig’s cell and spermatids. The ST have halted spermatogenesis, with irregular boundary and dead spermatogonia and Leydig’s cells are disorganized. The sperm head cross sectional area (CSA), tail length and middle piece diameter (p ≤ 0.001) significantly reduced while there is significant elevation of hepatocytes nuclei size, central vein CSA and mean width of Sinusoidal Spaces as compared to control. The protuberant marks of steatosis, fibrosis, dehydration and atrophy were nullified by designated fruit extracts and their possible bio-chelating effects was obvious due to the presence of anthocyanin, β-sitosterol and phytochemicals. The given results specify that hexavalent Cr induce andro-hepatic anomalies when it is freely used without scientific authentication. Cr+6 as food additives in coloring rice and local sweets should be prohibited while bio-products of Morus and Jamun can be recommended and sponsored for traditional medicines.