Synthesis, Characterization and Evaluation of Antibacterial activity of Amine-Boranes

Abstract

Amine-Boranes (AB) are an elite class of reagent and belongs to the Borane-Lewis family, has found extensive use in chemical synthesis. Interesting aspect of AB reagents are to display chemo selectivity among the functional groups. The present investigation highlights on the innovative, green synthesis and characterization of the three of unique AB complexes, including triethylamine-borane (aliphatic), aniline-borane (aromatic), and (aromatic substituted) N,N-dimethylaniline-borane (DMAB) under an open air condition. The 11B NMR technique was used to characterize the synthesized AB reagents. The chemical shift values obtained were in accordance with the results of previous research studies, and it's interesting to note that there is a difference in 11B-NMR chemical shift values between the borane complexes of aromatic and aliphatic amines. The antibacterial efficacy of three AB reagents has been stated for the first instance by using disc diffusion method against four bacterial strains: Escherichia coli, Salmonella typhimurium, Pseudomonas aeruginosa, and Staphylococcus aureus. When compared to other AB complexes, the DMAB reagent demonstrated significant antibacterial properties against the four different bacterial species.