Skip to content
Research Article Open access CC BY 4.0

Assessment of Oxidative Stress Level in HIV/AIDS Patients on HAART Treatments

Florence Oremeyi Elujoba, Samuel Oche Odeh, Kemakolam Amadi, Micheal Kehinde Elujoba, Habibu Tijjani, Oto-obong Idah, Nwibo Nkechi Lilian

Asian Journal of Biochemistry, Genetics and Molecular Biology · pp. 35–41 · Published 15 Oct 2022

10.9734/ajbgmb/2022/v12i4269

Abstract

Background: Human Immunodeficiency Virus (HIV) infection is associated with the production of reactive oxygen species (ROS) and secondarily cellular damage of varied severity. Highly active antiretroviral therapy (HAART) are currently the therapy of optimal considerations for HIV-infected patients. Aims: The present study was designed to assess the oxidative stress levels in people living with HIV/AIDS on HAART. Methods: A total of one hundred and twenty (120) patients attending the Jos University Teaching Hospital APIN Centre were recruited for the study following the inclusion criteria. Superoxide dismutase (SOD), reduced glutathione (GSH) and malondialdehyde (MDA) were evaluated in blood samples of recruited patients. Results: Superoxide dismutase (SOD) activities increased in control patients with no significant difference (p<0.05) compared with HAART. However, significant increases (p>0.05) were observed in reduced glutathione (GSH) concentration of control patients compared with HAART and HAART Naïve patients. More so, significant increase (p>0.05) was observed in malondialdehyde (MDA) of HAART Naïve patients compared with HAART treatment and control. No significant differences (p>0.05) was observed in alanine aminotransferase and creatinine in HAART, HAART Naïve compared with the control patients. Conclusion: The study indicated that HIV/AIDS positive patients express reduced levels of SOD, and GSH with an increase level of MDA. This could further lead to oxidative stress complications and thus HAART-naïve patients are encouraged to used HAART to prevent further complication that could arise from oxidative stress.

HAART oxidative stress markers HIV/AIDS treatment

References (18)

  1. 1 The Role of Superoxide Anion in the Autoxidation of Epinephrine and a Simple Assay for Superoxide Dismutase [DOI]
  2. 2 Improved method for the determination of blood glutathione.
  3. 3 Method for the measurement of antioxidant activity in human fluids [DOI]
  4. 4 Effects of Calmodulin Antagonists on Radiation-induced Lipid Peroxidation in Microsomes [DOI]
  5. 5 Oxidative Stress during HIV Infection: Mechanisms and Consequences [DOI]
  6. 6 The homeostatic role of hydrogen peroxide, superoxide anion and nitric oxide in the vasculature [DOI]
  7. 7 Oxidative Imbalance in HIV‐1 Infected Patients Treated with Antiretroviral Therapy [DOI]
  8. 8 Dietary antioxidants remodel DNA methylation patterns in chronic disease [DOI]
  9. 9 Oxidative Stress in HIV Patients Receiving Antiretroviral Therapy [DOI]
  10. 10 Physiological regulation of reactive oxygen species in organisms based on their physicochemical properties [DOI]
  11. 11 Urothelial cells produce hydrogen peroxide through the activation of Duox1 [DOI]
  12. 12 A natural antioxidant, tannic acid mitigates iron‐overload induced hepatotoxicity in Swiss albino mice through ROS regulation [DOI]
  13. 13 Oxidative stress, antioxidant capacity, biomolecule damage, and inflammation symptoms of sickle cell disease in children [DOI]
  14. 14 Mitochondrial and Oxidative Impacts of Short and Long-term Administration of HAART on HIV Patients [DOI]
  15. 15 Biomarkers of Oxidative Stress in HIV Seropositive Individuals on Highly Active Antiretroviral Therapy [DOI]
  16. 16 Effectiveness of Anti-retroviral Therapy (ART) on HIV-1 Patients Using Viral Load and CD4 Counts as Indices [DOI]
  17. 17 HIV-1 Antiretroviral Drug Therapy [DOI]
  18. 18 Adverse drug reactions to Antiretroviral drugs: Effect on virologic faliure in a Nigerian cohort of HIV-infected adults on first-line Antiretroviral therapy

Cited by 3

A Pilot Study on the Potential Pathological Link Between Oxidative Stress Markers and Renal Function in People Living with HIV

Joel Choshi, Haskly Mokoena, Helen C. Steel · International Journal of Molecular Sciences · 2025

Showing 1 of 3 known citations — external sources report more than can currently be individually listed.

Related research

Article metrics

Real usage data collected on this platform.

48

Page views

0

PDF downloads

13

Outbound clicks

3

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.