Association between Age Gain, Parkinsonism and Pesticides: A Public Health Problem?

Abstract

As life expectancy increases worldwide, so does the time available for prolonged exposure to toxic materials in the environment that have the potential to exert gradual pressure, facilitating the onset of aging in the body. Neural/behavioral alterations are linked to age gain, making the understanding of the aging process more complex considering the high complexity of the neural system and, although neuropsychological, pathological and neuroimaging criteria have been established to differentiate between normal and pathological aging, diagnosing the mild cognitive problems of each elderly individual remains a challenge. Parkinson's disease is recognized as one of the most common neurological disorders in the elderly, whose intrinsic cause is still unknown, but its main molecular basis is the decrease in dopamine produced in the substantia nigra. Studies have suggested that exposure to organophosphate, the glyphosate class, in different organisms, are capable of promoting bodily malformations, neurotoxicity, hepatotoxicity, genotoxicity, metabolic disorders, among others. The effects of pesticides on the environment, associated with their exacerbated permanence in the environment, indicate that more and more people may suffer their deleterious action, which may be the cause of some neurodegenerative disorders. The main objective of this study was to use specific data from the literature on Parkinsonism, correlating it with aging and contamination by pesticides. In fact, the health risks inherent in the use of pesticides are greater the greater the intensity of exposure to them and, considering the widespread use of pesticides today, the number of poisoning of the human population and animals will increase. Therefore, in terms of literary data, contamination with pesticides may be associated with a public health problem and, therefore, a possible increase in dementia processes, thus Parkinsonism.