Association of Obesity and Resistin Levels in Periodontal Disease

Abstract

Objectives:  The aim of this systematic review is to evaluate the association between obesity and resistin levels in periodontal disease. Methods: Search strategy included relevant articles from December 2010 to April 2021 using relevant key indexing terms such as PUBMED, Google scholar. Data were retrieved from 10 articles that were included in this review (2 cross sectional, 2 prospective, 6 case control studies). The total number of sample size taken ranged between 10 and 116 participants consisting both female and male individuals with a mean age between 20 and 65 years. The interrelation between obesity and resistin levels in periodontal disease were included in this systematic review. Results: Following screening through the electronic search out, a total of 45 articles were retrieved of which based on the inclusion criteria 10 studies were included in the review. Due to a lack of data, no meta-analysis was conducted but results from the studies indicated that there is an association between resistin levels in periodontitis patients with obesity. Conclusion: Individuals with obesity in chronic periodontitis patients had increased resistin levels when compared to healthy individuals in GCF, serum and saliva. Further investigation is required in order to support their relationship.