Phytochemical and Antioxidant Evaluation of Ethanolic Extracts of Hedranthera barteri on Female Albino Wister Rats

Abstract

Phytochemical and antioxidant evaluation of ethanolic extracts  of Hedranthera barteri leaves is an anti-inflammatory agent which exhibits both hyposecretive and cytoprotective effects. The aim of this study is to evaluate the phytochemical screening and antioxidant capacity of Hedranthera barteri leaves using female white albino rats. Ethanolic extraction of Hedranthera Barteri leaves was done using 70% ethanol. The sub-acute toxicity of the extract to the female albino Wister rats were monitored The results of Glutathion (GSH) concentration revealed that (p<0.05) there was no significant difference between different concentrations of Hedranthera barteri and chlomphene citrate compared to the control group. Results of superoxide dismutase (SOD) showed (p>0.05) that there was significant difference between 100mg/kg Hedranthera barteri and 200mg/kg Hedranthera Barteri compared with the control group. Also, the result of catalase (CAT) revealed that p>0.05 there was a significant difference between 100mg/kg Hedranthera Barteri compared to the control group. However, there was p<0.05 no significant difference between different concentrations of Hedranthera Barteri and clomiphene citrate compared to the control group of malonaldehyde (MDA). The results above indicated that Hedranthera Barteri leaves extracts is capable of scavenging free radicals. The female albino Wister rats did not show signs of toxicity or mortality. The presence of phenols, alkaloids, tannins, flavonoids, phlobatanin and terpenoids may be responsible for the antioxidant activities of the extracts.