Anticonvulsant Activity of Elaesis guineensis (Jacq) Oil in Pentylenetetrazol-Induced Seizure in Drosophila melanogaster

Abstract

Elaesis guineensis, a plant whose oil extract (palm kernel oil) is medicinal, is reported to treat a wide range of disorders, including seizures. However, the anticonvulsant activity of this oil extract has not been exhaustively studied. This study aimed at evaluating the anticonvulsant activity of Elaesis guineensis oil in pentylenetetrazol-induced seizure in Drosophila melanogaster (fruit-fly). Pentylenetetrazol (50 mg/5 g diet) was used to induce seizure in Drosophila melanogaster. Flies were exposed to different concentrations (0.5-5%) of the oil and phenytoin for 28 days in a survival assay to determine the safety in the fruit flies. Five replicate of fifty files each were exposed to diet containing the LC50 of phenytoin and other groups were exposed to different concentrations of the extract for 7 days. Seizure was then induced with Pentylenetetrazol. The Trikinetic system was used to monitor activity and the DAMSystem3 data collection program to collect, process and store data. The results showed that the extract increased the latency of seizures and improved survival in the flies and suggest that the extract possesses anticonvulsant properties.